Is it Piriformis or Sciatica? Best Self Test for Piriformis Syndrome What's Piriformis Syndrome? Piriformis syndrome is a condition that results when the piriformis muscle becomes tight and compresses the sciatic nerve. The result is pain, tingling, numbness, and weakness in the buttocks and leg. The sciatic nerve is also involved, which is why it's often mistaken for sciatica.
