Anisodamine: Difference between revisions

{{Short description|Chemical compound}}

| Watchedfields = changed

| verifiedrevid =

| IUPAC_name = [(,,,)-7-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ()-3-hydroxy-2-phenyl-propanoate

| image = Anisodamine.svg

| synonyms = 7''β''-hydroxyhyoscyamine

<!--Clinical data-->

| tradename =

| pregnancy_category=

| legal_status

| routes_of_administration =

<!--Pharmacokinetic data-->

| bioavailability

| protein_bound

| metabolism

| elimination_half-life =

| excretion =

<!--Identifiers-->

| = {{|correct|}}

| CAS_number = 55869-99-3

| ATC_prefix = None

| ATC_suffix

| PubChem = 183088

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 159209

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 01343Q8EL8

<!--Chemical data-->

| C=17 | H=23 | N=1 | O=4

| smiles = O=C(O[C@@H]1C[C@@H]2N(C)[C@H](C1)C[C@@H]2O)[C@@H](c3ccccc3)CO

'''Anisodamine''', also known as '''7''β''-hydroxyhyoscyamine''', is an [[anticholinergic]] and [[-|α₁ ]] [[ antagonist] used in the treatment of [[ circulatory shock]] in [[China]].<ref name="pmid2879586">{{cite journal | = Varma DR, Yue TL | title = Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats | journal = British Journal of Pharmacology | volume = 87 | issue = 3 | pages = 587–94 |= 1986 | pmid = 2879586 | pmc = 1916562 | doi = }}</ref> It is [[ ]] .<ref>{{cite |= .|= |=|=|=|=|=|=|doi=10./j..2008..|url=http://..com//--}}</ref>

Anisodamine is a [[natural|naturally occurring]] [[tropane]] [[alkaloid]] found in some plants of the family [[Solanaceae]] including [[Datura]].<ref name="pmid23868645">{{cite journal |vauthors=Ye N, Li J, Gao C, Xie Y |title=Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide |journal=[[Journal of Separation Science]] |volume=36 |issue=16 |pages=2698–702 |date=August 2013 |pmid=23868645 |doi=10.1002/jssc.201300304 |url= |issn=}}</ref><ref name="pmid18672024">{{cite journal | vauthors = Zhang WW, Song MK, Cui YY | title = Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine | journal = Neuroscience Letters | volume = 443 | issue = 3 | pages = 241–5 |date=October 2008 | pmid = 18672024 | doi = 10.1016/j.neulet.2008.07.048 | s2cid = 2730169 |display-authors=etal}}</ref> Its Mandarin Chinese name {{lang|zh-Hans-CN|山莨菪[[wikt:碱|碱]]}} is given after ''[[Anisodus tanguticus]]'' ({{zh|t=[[wiktionary:山|山]][[wiktionary:莨|莨]][[wiktionary:菪|菪]]|p=shān làng dàng}}).<ref>{{cite web|title=消旋山莨菪碱|url=http://www.yaobiaozhun.com/yd2015/view.php?v=txt&id=4045|publisher=中国药典|access-date=3 December 2017|archive-url=https://archive.today/20171203013717/http://www.yaobiaozhun.com/yd2015/view.php?v=txt&id=4045|archive-date=2017-12-03|language=zh-CN}}</ref>

* [[Atropine]], used for similar cardiac and optamological purposes elsewhere

{{Reflist}}

{{Adrenergic receptor modulators}}

{{Muscarinic acetylcholine receptor modulators}}

[[Category:Alpha- ]]

[[Category:]]

[[Category:Tropane alkaloids]]

[[Category:Tropane alkaloids found in Solanaceae]]

{{-stub}}