EGLU: Difference between revisions

{{drugbox

| verifiedrevid = 400017499

| IUPAC_name = (2S)-2-amino-2-ethylpentanedioic acid

| image = Salpha_ethylglutamic_acid.png

| width = 160

| CAS_number =

| ATC_prefix =

| ATC_suffix =

| PubChem = 5311079

| DrugBank =

| C=7|H=13|N=1|O=4

| molecular_weight = 175.182 g/mol

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->

| pregnancy_US = <!-- A / B / C / D / X -->

| pregnancy_category=

| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->

| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->

| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->

| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->

| legal_status =

| routes_of_administration =

'''(2S)-α-Ethylglutamic acid''' ('''EGLU''') is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors ([[Metabotropic glutamate receptor|mGluR_2/3]]), and so has been useful in the characterisation and study of this receptor subfamily.<ref>{{cite journal | last1 = Jane | first1 = DE | last2 = Thomas | first2 = NK | last3 = Tse | first3 = HW | last4 = Watkins | first4 = JC | title = Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord | journal = Neuropharmacology | volume = 35 | issue = 8 | pages = 1029–35 | year = 1996 | pmid = 9121605 }}</ref><ref>{{cite journal | last1 = Huang | first1 = L | last2 = Rowan | first2 = MJ | last3 = Anwyl | first3 = R | title = Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro | journal = European journal of pharmacology | volume = 366 | issue = 2-3 | pages = 151–8 | year = 1999 | pmid = 10082195 | doi=10.1016/S0014-2999(98)00918-2}}</ref><ref>{{cite journal | last1 = Palazzo | first1 = E | last2 = Marabese | first2 = I | last3 = De Novellis | first3 = V | last4 = Oliva | first4 = P | last5 = Rossi | first5 = F | last6 = Berrino | first6 = L | last7 = Rossi | first7 = F | last8 = Maione | first8 = S | title = Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception | journal = Neuropharmacology | volume = 40 | issue = 3 | pages = 319–26 | year = 2001 | pmid = 11166324 | doi=10.1016/S0028-3908(00)00160-X}}</ref><ref>{{cite journal | last1 = Iserhot | first1 = C | last2 = Gebhardt | first2 = C | last3 = Schmitz | first3 = D | last4 = Heinemann | first4 = U | title = Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat | journal = Brain research | volume = 1027 | issue = 1-2 | pages = 151–60 | year = 2004 | pmid = 15494166 | doi = 10.1016/j.brainres.2004.08.052 }}</ref><ref>{{cite journal | last1 = Cahusac | first1 = PM | last2 = Wan | first2 = H | title = Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo | journal = Neuroscience | volume = 146 | issue = 1 | pages = 202–12 | year = 2007 | pmid = 17346894 | doi = 10.1016/j.neuroscience.2007.01.049 }}</ref><ref>{{cite journal | last1 = Kim | first1 = WY | last2 = Vezina | first2 = P | last3 = Kim | first3 = JH | title = Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment | journal = Behavioural brain research | volume = 191 | issue = 1 | pages = 62–6 | year = 2008 | pmid = 18433894 | doi = 10.1016/j.bbr.2008.03.010 }}</ref><ref>{{cite journal | last1 = Altinbilek | first1 = B | last2 = Manahan-Vaughan | first2 = D | title = A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory | journal = Neuroscience | volume = 158 | issue = 1 | pages = 149–58 | year = 2009 | pmid = 18722513 | doi = 10.1016/j.neuroscience.2008.07.045 }}</ref>

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{{Glutamate_receptor_ligands}}

[[Category:Neuroscience]]

{{pharmacology-stub}}