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{{short description|Ore of lanthanum metal}}
{{Chembox
{{Chembox
| Verifiedfields = changed
| Name = Lanthanum carbonate
| Watchedfields = changed
| ImageFile =
| verifiedrevid = 400130079
<!-- | ImageSize = 200px -->
| Name = Lanthanum carbonate
| ImageName =
| IUPACName = Lanthanum carbonate
| = Lanthanumcarbonate
| OtherNames =
| =
| IUPACName = Lanthanum carbonate
| Section1 = {{Chembox Identifiers
| OtherNames = Fosrenol
| ChemSpiderID = 147758
|Section1={{Chembox Identifiers
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 147758
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 2096647
| PubChem = 168924
| PubChem = 168924
| KEGG = D04667
| InChI = 1/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
| InChI = 1/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
| InChIKey = NZPIUJUFIFZSPW-CYFPFDDLAT
| InChIKey = NZPIUJUFIFZSPW-CYFPFDDLAT
| SMILES = [La+3].[La+3].O=C([O-])[O-].[O-]C([O-])=O.[O-]C([O-])=O
| SMILES = [La+3].[La+3].O=C([O-])[O-].[O-]C([O-])=O.[O-]C([O-])=O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
| StdInChI = 1S/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = NZPIUJUFIFZSPW-UHFFFAOYSA-H
| StdInChIKey = NZPIUJUFIFZSPW-UHFFFAOYSA-H
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 54451-24-0
| RTECS =
| =
| UNII_Ref = {{fdacite|correct|FDA}}
}}
| UNII = 0M78EU4V9H
| Section2 = {{Chembox Properties
| EC_number = 209-599-5
| Formula = La<sub>2</sub>(CO<sub>3</sub>)<sub>3</sub>
}}
| MolarMass = 457.85 g/mol
|Section2={{Chembox Properties
| Appearance = White, hygroscopic
| Formula = La{{sub|2}}(CO<sub>3</sub>)<sub>3</sub>
| Density = 2.6–2.7 g/cm{{sup|3}}
| MolarMass = 457.838 g/mol
| Solubility = Insoluble
| Appearance = White powder, hygroscopic
| MeltingPt = ''decomposes''
| Density = 2.6–2.7 g/cm{{sup|3}}
| BoilingPt =
| Solubility = negligible
| pKa =
| SolubleOther = soluble in acids
| pKb =
| MeltingPt = ''decomposes''
| BoilingPt =
| pKa =
| pKb =
}}
}}
| Section3 = {{Chembox Structure
|Section3={{Chembox Structure
| Coordination =
| Coordination =
| CrystalStruct =
| CrystalStruct =
| Dipole =
| Dipole =
}}
}}
| Section7 = {{Chembox Hazards
| = {{Chembox
| Pharmacology_ref =
| ExternalMSDS =
| MainHazards =
| =
| FlashPt =
| =
| RPhrases =
| =
| SPhrases =
| =
| Licence_EU =
| INN =
| INN_EMA =
| Licence_US =
| Legal_status =
| Legal_AU =
| Legal_AU_comment =
| Legal_CA = Rx-only
| Legal_CA_comment =
| Legal_NZ =
| Legal_NZ_comment =
| Legal_UK =
| Legal_UK_comment =
| Legal_US =
| Legal_US_comment =
| Legal_EU =
| Legal_EU_comment =
| Legal_UN =
| Legal_UN_comment =
| Pregnancy_category =
| Pregnancy_AU =
| Pregnancy_AU_comment =
| Dependence_liability =
| AdminRoutes =
| Bioavail =
| ProteinBound =
| Metabolism =
| Metabolites =
| OnsetOfAction =
| HalfLife =
| DurationOfAction =
| Excretion =
}}
}}
| Section8 = {{Chembox Related
|={{Chembox
| ExternalSDS =
| OtherAnions = [[Lanthanum(III) oxide]]
| OtherCpds =
| =
| FlashPt =
}}
}}
|Section8={{Chembox Related
| OtherAnions = [[Lanthanum(III) oxide]]
| OtherCompounds =
}}
}}
}}
'''Lanthanum carbonate''', [[Lanthanum|La]]<sub>2</sub>([[Carbon|C]][[Oxygen|O]]<sub>3</sub>)<sub>3</sub>, is the [[salt]] formed by [[lanthanum]](III) [[cation]]s and [[carbonate]] [[anion]]s. It is an ore of [[lanthanum]] metal, along with [[monazite]].
'''Lanthanum carbonate''', [[Lanthanum|La]]{{sub|2}}([[Carbon|C]][[Oxygen|O]]<sub>3</sub>)<sub>3</sub>, is the [[salt (chemistry)|salt]] formed by [[lanthanum]](III) [[cation]]s and [[carbonate]] [[anion]]s. It is an ore of [[lanthanum]] metal ([[bastnäsite]]), along with [[monazite]].


== Chemistry ==
== Chemistry ==
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* for production of certain [[High-temperature superconductivity|high-temperature superconductors]], such as La{{sub|2-''x''}}Sr{{sub|''x''}}CuO{{sub|2}}.
* for production of certain [[High-temperature superconductivity|high-temperature superconductors]], such as La{{sub|2-''x''}}Sr{{sub|''x''}}CuO{{sub|2}}.


== Medical uses ==
== Human and veterinary medicine ==
Lanthanum carbonate is used in [[medicine]] as a [[phosphate binder]]<ref>{{cite web | last = Editorial Staff | title = Lanthanum Carbonate | work = All Micromedex Systems | publisher = Micromedex, Inc. | month = December | year = 2004 | url = http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html | accessdate = 2007-11-25 |archiveurl = http://web.archive.org/web/20070914035811/http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html <!-- Bot retrieved archive --> |archivedate = 2007-09-14}}</ref>. As a medication it is sold under the trade name '''Fosrenol''' by the pharmaceutical company [[Shire Pharmaceuticals]]. Fosrenol is the largest of all pills filled in community pharmacies. Sometimes patients forget that fosrenol is not swallowed whole, but instead should be chewed. This has led to severe choking. It is [[medical prescription|prescribed]] for the treatment of [[hyperphosphatemia]], primarily in patients with [[chronic kidney disease]]. It is taken with meals and binds to dietary [[phosphate]], preventing phosphate from being absorbed by the [[intestine]]. For cats suffering from [[hyperphosphatemia]] it is available under the trade name '''Renalzin''' by [[Bayer|Bayer Animal Health]].<ref>{{cite web | author = Bayer Animal Health | url = http://www.animalhealth.bayerhealthcare.com/fileadmin/presslounge/att/2008-09-0441E.pdf |format=PDF| date = 26 September 2008 | title = Bayer Animal Health launches Renalzin for Cats | accessdate = 2008-09-30}}</ref>
Lanthanum carbonate is used in [[medicine]] as a [[phosphate binder]]<ref>{{cite web|last=Editorial Staff |title=Lanthanum Carbonate |work=All Micromedex Systems |publisher=Micromedex, Inc. |=December 2004 |url=http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html |accessdate=2007-11-25 |archiveurl=://web.archive.org/web/20070914035811/http://www.micromedex.com/products/updates/drugdex_updates/de/lanthanum.html |archivedate=2007-09-14}}</ref> As a medication it is sold under the trade name '''Fosrenol''' by the pharmaceutical company [[Shire Pharmaceuticals]]. in chewed. It is [[medical prescription|prescribed]] for the treatment of [[hyperphosphatemia]], primarily in patients with [[chronic kidney disease]]. It is taken with meals and binds to dietary [[phosphate]], preventing phosphate from being absorbed by the [[intestine]]. For cats [[hyperphosphatemia]] it is available under the trade name '''Renalzin''' by [[Bayer|Bayer Animal Health]].<ref>{{cite web | author = Bayer Animal Health | url = http://www.animalhealth.bayerhealthcare.com/fileadmin/presslounge/att/2008-09-0441E.pdf | date = 26 September 2008 | title = Bayer Animal Health launches Renalzin for Cats | accessdate = 2008-09-30}}</ref>

However, when lanthanum carbonate is used for treating hyperphosphatemia, its side effects, namely [[myalgia]], muscular cramping, and [[peripheral edema]], should be clinically monitored.<ref>{{cite journal |doi=10.1056/NEJMra0912522|pmid=20375408|title=Oral Phosphate Binders in Patients with Kidney Failure|journal=New England Journal of Medicine|volume=362|issue=14|pages=1312–24|year=2010|last1=Tonelli|first1=Marcello|last2=Pannu|first2=Neesh|last3=Manns|first3=Braden|s2cid=22322676}}</ref>


== Other applications ==
== Other applications ==
Lanthanum carbonate is also used for the tinting of glass, for water treatment, or as a [[Catalysis|catalyst]] for [[cracking (chemistry)|hydrocarbon cracking]].
Lanthanum carbonate is also used for the tinting of glass, for water treatment, as a [[Catalysis|catalyst]] for [[cracking (chemistry)|hydrocarbon cracking]].


== References ==
== References ==
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== External links ==
== External links ==
* [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a605015.html Lanthanum] - medlineplus.org
* [://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a605015.html Lanthanum] - medlineplus.org
* [http://www.fosrenol.com/Consumers/Default.aspx Fosrenol.com] - the manufacturer's web site
* [://.fosrenol.com/Consumers/Default.aspx Fosrenol.com] - the manufacturer's web site
* [http://www.drugs.com/NDA/fosrenol_040720.html Fosrenol] - Drugs.com
* [://www.drugs.com/NDA/fosrenol_040720.html Fosrenol] - Drugs.com
* [http://www.medscape.com/pages/sites/infosite/fosrenol/fosrenol-intro?src=hp17.isite Fosrenol] - Medscape.com
* [http://www.medscape.com/pages/sites/infosite/fosrenol/fosrenol-intro?src=hp17.isite Fosrenol] - Medscape.com
* [http://www.phosphoruscontrol.com PhosphorusControl.com] - PhosphorusControl.com
* [://.phosphoruscontrol.com PhosphorusControl.com] - PhosphorusControl.com
* [http://www.animalhealth.bayerhealthcare.com Bayer Animal Health]
* [http://www.animalhealth.bayerhealthcare.com Bayer Animal Health]

{{Lanthanum compounds}}
{{Lanthanum compounds}}
{{Carbonates}}
{{Drugs for treatment of hyperkalemia and hyperphosphatemia}}
{{Drugs for treatment of hyperkalemia and hyperphosphatemia}}


[[Category:Nephrology procedures]]
[[Category:Phosphate binders]]
[[Category:Phosphate binders]]
[[Category:Lanthanum compounds]]
[[Category:Lanthanum compounds]]
[[Category:Carbonates]]
[[Category:Carbonates]]
[[Category:Metal-containing drugs]]

[[Category:Drugs developed by Takeda Pharmaceutical Company]]
[[de:Lanthancarbonat]]
[[es:Carbonato de lantano]]
[[nl:Lanthaniumcarbonaat]]
[[sr:Лантан-карбонат]]
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