Caliak sumber untuak Insulin

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Sanak dapek mancaliak atau manyalin sumber laman iko:

{{#invoke:Infobox_gene|getTemplateData|QID=Q21163221}}
[[Berkas:Insulin.jpg|ka|jmpl|300px|Model struktur insulin {{br}} Sirah: [[karbon]]; ijau: [[oksigen]]; biru: [[nitrogen]]; sirah mudo: [[sulfur]]. Pita biru/ungu merupokan kerangko <nowiki>[-N-C-C-]</nowiki>n dalam sekuens [[asam amino]] <nowiki>H-[-NH-CHR-CO-]</nowiki>n-OH protein tasabuik, jo R marupokan bagian yang menonjol dari kerangko tasabuik pado satiok asam amino.]]

'''Insulin''' ([[bahaso Latin]] ''insula'', "pulau", dek diproduksi di [[Pulau-pulau Langerhans]] di [[pankreas]]) adolah sabuah [[hormon]] [[polipeptida]] nan mangatur [[metabolisme karbohidrat]]. Salain merupokan "efektor" utamo dalam [[homeostasis]] [[karbohidrat]], hormon iko juo ambia bagian dalam metabolisme [[lemak]] ([[trigliserida]]) jo [[protein]] – hormon iko basifat [[anabolisme|anabolik]] nan artinyo maningkekkan panggunoan protein. Hormon tasabuik jugi mamangaruhi jaringan badan lainnyo.

Insulin menyababkan [[sel (biologi)]] pado [[otot]] jo [[adiposit]] manyerap [[glukosa]] dari sirkulasi darah malalui [[transporter glukosa]] GLUT1 jo GLUT4<ref>{{en}} {{cite web
| url          = http://jcb.rupress.org/content/114/4/689.abstract
| title        = Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type
| accessdate   = 2010-05-01
| work         = Rockefeller University; P M Haney, J W Slot, R C Piper, D E James, M Mueckler.
}}</ref> jo menyimpannyo sabagai [[glikogen]] di dalam hati jo otot sabagai sumber energi.

Kadar insulin nan randah akan melangurangi penyerapan glukosa sahinggo tubuah akan mulai manggunokan [[lemak]] sabagai sumber energi.

Insulin digunokan dalam pangobatan babarapo jenis [[diabetes mellitus]]. Pasien jo panyakik diabetes mellitus tipe 1 bagantuang pado insulin eksogen (disuntikkan ka bawah kulik/subkutan) untauk keselamatannyo dek kakurangan absolut hormon tasabuik; pasien jo diabetes mellitus tipe 2 mampunyoi tingkek produksi insulin randah atau [[kebal insulin]], jo kadang kala mambutuhkan pangaturan insulin bili pangobatan lain indak cukuik untuak menangatur kadar glukosa darah.

== Caliak pulo ==
* [[anatomi]] jo [[fisiologi]]
** [[glukagon]]
** [[pankreas]]
** [[Pulau-pulau Langerhans]]
** [[endokrinologi]]
* janih diabetes mellitus
** [[diabetes mellitus]]
*** [[diabetes mellitus tipe 1]]
*** [[diabetes mellitus tipe 2]]
** [[diabetes insipidus]]
* perawatan
** ''[[Diabetic coma]]''
** [[insulinoterapi intensif]]
** [[pompa insulin]]
** [[insulinoterapi konvensional]]

==Refrensi==
{{Reflist}}

== Pranala luar ==
* {{en}} [http://nist.rcsb.org/pdb/molecules/pdb14_1.html Insulin: entry from protein databank] {{Webarchive|url=https://web.archive.org/web/20050316215351/http://nist.rcsb.org/pdb/molecules/pdb14_1.html |date=2005-03-16 }}
* {{en}} [http://www.med.uni-giessen.de/itr/history/inshist.html Sejarah Insulin] {{Webarchive|url=https://web.archive.org/web/20181101104524/http://www.med.uni-giessen.de/itr/history/inshist.html |date=2018-11-01 }}

{{Hormon}}
{{Authority control}}

[[Kategori:Hormon]]
[[Kategori:Diabetes]]
[[Kategori:Produk hewan]]
[[Kategori:Ubek Esensial Nasional Indonesia]]
[[Kategori:Antidiabetik]]

Templat nan digunoan di laman ko:

Baliak ka Insulin

Diambiak dari "https://min.wikipedia.org/wiki/Insulin"