ARID1A

AT rich interactive domain 1A (SWI-like)
	Renderização PDB baseada em 1ryu.
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1RYU
Identificadores
Símbolos	ARID1A; B120; BAF250; BAF250a; BM029; C1orf4; ELD; MRD14; OSA1; P270; SMARCF1; hELD; hOSA1
IDs externos	OMIM: 603024 MGI: 1935147 HomoloGene: 21216 GeneCards: ARID1A Gene
Ontologia do gene
Função molecular	•DNA binding; •transcription coactivator activity; •protein binding; •ligand-dependent nuclear receptor binding; •nucleosome binding;
Componente celular	•nuclear chromatin; •nucleus; •nucleolus; •SWI/SNF complex; •npBAF complex; •nBAF complex;
Processo biológico	•negative regulation of transcription from RNA polymerase II promoter; •neural tube closure; •cardiac chamber development; •optic cup formation involved in camera-type eye development; •nucleosome disassembly; •chromatin remodeling; •transcription, DNA-templated; •regulation of transcription from RNA polymerase II promoter; •intracellular estrogen receptor signaling pathway; •androgen receptor signaling pathway; •forebrain development; •nucleosome mobilization; •glucocorticoid receptor signaling pathway; •ATP-dependent chromatin remodeling; •positive regulation of transcription, DNA-templated; •chromatin-mediated maintenance of transcription; •placenta blood vessel development;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

AT-rich interactive domain-containing protein 1A é uma proteína humana que é codificada pelo gene ARID1A.^[1]^[2]^[3] Este gene codifica uma proteína liga a família SWI/SNF, cujos membros possuem atividade do tipo helicase e ATPase e estão envolvidos na transcrição de determinados genes por meio da alteração da estrutura da cromatina na região que abriga os ditos genes.

Estudos do Centro para Câncer Johns Hopkins Kimmel publicados em setembro de 2010 na revista Science demonstraram que está relacionada com o câncer de ovário. Neste caso, impede a formação de tumores.^[4]

Interações

ARID1A mostrou interação com SMARCB1^[5]^[6] e SMARCA4.^[6]^[7]

Notas e referências

↑ Takeuchi T, Furihata M, Heng HH, Sonobe H, Ohtsuki Y (1998). «Chromosomal mapping and expression of the human B120 gene». Gene. 213 (1-2): 189–93. PMID 9630625. doi:10.1016/S0378-1119(98)00194-2
↑ Takeuchi T, Chen BK, Qiu Y, Sonobe H, Ohtsuki Y (1998). «Molecular cloning and expression of a novel human cDNA containing CAG repeats». Gene. 204 (1-2): 71–7. PMID 9434167. doi:10.1016/S0378-1119(97)00525-8
↑ «Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)»
↑ G1. «Estudo nos EUA identifica dois genes ligados ao câncer de ovário». Consultado em 9 de setembro de 2010
↑ Kato, Hiroyuki; Tjernberg Agneta, Zhang Wenzhu, Krutchinsky Andrew N, An Woojin, Takeuchi Tamotsu, Ohtsuki Yuji, Sugano Sumio, de Bruijn Diederik R, Chait Brian T, Roeder Robert G (2002). «SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones». United States. J. Biol. Chem. 277 (7): 5498–505. ISSN 0021-9258. PMID 11734557. doi:10.1074/jbc.M108702200
↑ ^a ^b Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (1996). «Purification and biochemical heterogeneity of the mammalian SWI-SNF complex». ENGLAND. EMBO J. 15 (19): 5370–82. ISSN 0261-4189. PMC 452280 . PMID 8895581
↑ Zhao, K; Wang W, Rando O J, Xue Y, Swiderek K, Kuo A, Crabtree G R (1998). «Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling». UNITED STATES. Cell. 95 (5): 625–36. ISSN 0092-8674. PMID 9845365. doi:10.1016/S0092-8674(00)81633-5

Leitura de apoio

Martens JA, Winston F (2003). «Recent advances in understanding chromatin remodeling by Swi/Snf complexes.». Curr. Opin. Genet. Dev. 13 (2): 136–42. PMID 12672490. doi:10.1016/S0959-437X(03)00022-4
Maruyama K, Sugano S (1994). «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.». Gene. 138 (1-2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8
Wang W, Xue Y, Zhou S; et al. (1996). «Diversity and specialization of mammalian SWI/SNF complexes.». Genes Dev. 10 (17): 2117–30. PMID 8804307. doi:10.1101/gad.10.17.2117
Wang W, Côté J, Xue Y; et al. (1996). «Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.». EMBO J. 15 (19): 5370–82. PMC 452280 . PMID 8895581
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.». Gene. 200 (1-2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3
Dallas PB, Cheney IW, Liao DW; et al. (1998). «p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes.». Mol. Cell. Biol. 18 (6): 3596–603. PMC 108941 . PMID 9584200
Dallas PB, Pacchione S, Wilsker D; et al. (2000). «The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity.». Mol. Cell. Biol. 20 (9): 3137–46. PMC 85608 . PMID 10757798. doi:10.1128/MCB.20.9.3137-3146.2000
Nie Z, Xue Y, Yang D; et al. (2000). «A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex.». Mol. Cell. Biol. 20 (23): 8879–88. PMC 86543 . PMID 11073988. doi:10.1128/MCB.20.23.8879-8888.2000
Takeuchi T, Nicole S, Misaki A; et al. (2001). «Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma.». Am. J. Pathol. 158 (2): 663–72. PMC 1850330 . PMID 11159203
Kozmik Z, Machon O, Králová J; et al. (2001). «Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex.». Genomics. 73 (2): 140–8. PMID 11318604. doi:10.1006/geno.2001.6477
Kato H, Tjernberg A, Zhang W; et al. (2002). «SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.». J. Biol. Chem. 277 (7): 5498–505. PMID 11734557. doi:10.1074/jbc.M108702200
Lemon B, Inouye C, King DS, Tjian R (2002). «Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.». Nature. 414 (6866): 924–8. PMID 11780067. doi:10.1038/414924a
Hurlstone AF, Olave IA, Barker N; et al. (2002). «Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.». Biochem. J. 364 (Pt 1): 255–64. PMC 1222568 . PMID 11988099
Inoue H, Furukawa T, Giannakopoulos S; et al. (2003). «Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.». J. Biol. Chem. 277 (44): 41674–85. PMID 12200431. doi:10.1074/jbc.M205961200
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899
Nie Z, Yan Z, Chen EH; et al. (2003). «Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.». Mol. Cell. Biol. 23 (8): 2942–52. PMC 152562 . PMID 12665591. doi:10.1128/MCB.23.8.2942-2952.2003
Kitagawa H, Fujiki R, Yoshimura K; et al. (2003). «The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome.». Cell. 113 (7): 905–17. PMID 12837248. doi:10.1016/S0092-8674(03)00436-7

Ligações externas

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma - Resumo^{[ligação inativa]}

[pmid9630625-1] Takeuchi T, Furihata M, Heng HH, Sonobe H, Ohtsuki Y (1998). «Chromosomal mapping and expression of the human B120 gene». Gene. 213 (1-2): 189–93. PMID 9630625. doi:10.1016/S0378-1119(98)00194-2

[pmid9434167-2] Takeuchi T, Chen BK, Qiu Y, Sonobe H, Ohtsuki Y (1998). «Molecular cloning and expression of a novel human cDNA containing CAG repeats». Gene. 204 (1-2): 71–7. PMID 9434167. doi:10.1016/S0378-1119(97)00525-8

[entrez-3] «Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)»

[4] G1. «Estudo nos EUA identifica dois genes ligados ao câncer de ovário». Consultado em 9 de setembro de 2010

[pmid11734557-5] Kato, Hiroyuki; Tjernberg Agneta, Zhang Wenzhu, Krutchinsky Andrew N, An Woojin, Takeuchi Tamotsu, Ohtsuki Yuji, Sugano Sumio, de Bruijn Diederik R, Chait Brian T, Roeder Robert G (2002). «SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones». United States. J. Biol. Chem. 277 (7): 5498–505. ISSN 0021-9258. PMID 11734557. doi:10.1074/jbc.M108702200

[pmid8895581-6] Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (1996). «Purification and biochemical heterogeneity of the mammalian SWI-SNF complex». ENGLAND. EMBO J. 15 (19): 5370–82. ISSN 0261-4189. PMC 452280 . PMID 8895581

[pmid9845365-7] Zhao, K; Wang W, Rando O J, Xue Y, Swiderek K, Kuo A, Crabtree G R (1998). «Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling». UNITED STATES. Cell. 95 (5): 625–36. ISSN 0092-8674. PMID 9845365. doi:10.1016/S0092-8674(00)81633-5

[1]