Large language models (LLMs) have shown excellent performance on various tasks, but the astronomical model size raises the hardware barrier for serving (memory size) and slows down token generation (memory bandwidth). In this paper, we propose Activation-aware Weight Quantization (AWQ), a hardware-friendly approach for LLM low-bit weight-only quantization. Our method is based on the observation that weights are not equally important: protecting 1% of salient weights can greatly reduce quantization error. We then propose to search for the optimal per-channel scaling that protects the salient weights by observing the activation, not weights. AWQ does not rely on any backpropagation or reconstruction, so it can well preserve LLMs' generalization ability on different domains and modalities, without overfitting to the calibration set. AWQ outperforms existing work on various language modeling and domain-specific benchmarks. Thanks to better generalization, it achieves excellent quantization performance for instruction-tuned LMs and, for the first time, multi-modal LMs. Alongside AWQ, we implement an efficient and flexible inference framework tailored for LLMs on the edge, offering more than 3x speedup over the Huggingface FP16 implementation on both desktop and mobile GPUs. It also democratizes the deployment of the 70B LLaMA-2 model on mobile GPUs.