When creating a new campaign for an advertiser, we generally suggest you structure your insertion orders based on the stages of the "sales funnel":
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Top of the funnel
Prospecting uses very broad targeting to discover which users are receptive to your ads.
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Mid funnel
Behaviorally targeting uses slightly more specific targeting that are intended to refine your existing audience lists and discover new audiences that are similar to your target audience.
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Bottom of the funnel
Remarketing uses pixels — or Floodlight, if your advertiser uses Campaign Manager 360 —to target users who have been to your advertiser's pages in the past.
General guidelines for new insertion orders
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Use insertion order and line item frequency caps to limit the maximum number times an individual user sees your ads.
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Consider using automatic budget allocation so that Display & Video 360 can automatically reallocate your line items' budgets based on performance. Otherwise, keep your line items' budgets flexible when they're just starting out, and then reallocate their budgets manually based on their performance relative to each other.