Astex Pharmaceuticals
| Company type | Subsidiary |
|---|---|
| Industry | Pharmaceuticals |
| Founded | 1999 |
| Headquarters | European Corporate and Research headquarters in Cambridge, UK (Astex Therapeutics Limited) |
Key people | Harren Jhoti (President and CEO) David Rees (Chief Scientific Officer) |
| Products | Therapeutics for oncology and CNS disorders |
| Parent | Otsuka Pharmaceutical  |
| Website | astx |
Astex Pharmaceuticals is a biotechnology company focused on the discovery and development of drugs in oncology and diseases of the central nervous system. Astex was founded in 1999 by Sir Tom Blundell,[1][2] Chris Abell & Harren Jhoti,[3] and is located in Cambridge, England.[4][5][6][7][8]
Astex is part of the Otsuka group of companies and is a wholly-owned subsidiary of Otsuka Pharmaceutical Co. Ltd, headquartered in Tokyo, Japan.[9]
History
[edit]Astex was founded as “Astex Technology Limited” in 1999 in Cambridge, UK, to pioneer a novel approach to small molecule drug discovery known as ‘fragment-based drug discovery’ (FBDD), a term first coined by Astex scientists (https://pubmed.ncbi.nlm.nih.gov/12650591/) that is now a well recognised approach to small molecule drug discovery across the pharmaceutical industry. Astex's proprietary drug discovery platform, Pyramid, can effectively identify novel small molecule drugs for key disease targets. Originally funded by venture capital, from a number of investors including Abingworth, Advent international, Oxford Bioscience Partners, Apax Partners and Gimv. Astex established strategic partnerships with major pharmaceutical companies including Novartis, Janssen Pharmaceuticals and GlaxoSmithKline.
In 2005, the Company changed its name to Astex Therapeutics Limited when its first product entered clinical development. In 2011, Astex Therapeutics Limited and SuperGen, Inc. (US) merged.[10] Following the acquisition, SuperGen, Inc. changed its name to Astex Pharmaceuticals, Inc., and began trading under the ticker symbol ASTX on NASDAQ.[11] The combined Astex entities were subsequently acquired by Otsuka Pharmaceutical in October 2013 for around USD $900 million. On January 1, 2024, as part of an internal re-organization to consolidate oncology clinical development within the Otsuka group, Astex Pharmaceuticals, Inc., became part of Taiho Oncology, Inc. This internal reorganization did not impact the drug discovery research operation of Astex Pharmaceuticals (UK), based in Cambridge, UK, which continues to operate independently as ‘Astex’.
Research and development
[edit]Astex is focused on precision medicine for oncology and central nervous system disorders. This approach involves first understanding the molecular basis of a disease and then developing a targeted therapy which can arrest or reverse its progression.
Astex’s Pyramid platform[12] assists with the rational design of novel small molecule targeted therapies. These therapies are based on the use of biophysical techniques, principally X-ray crystallography, to screen and identify very small, low molecular weight fragments of drugs binding into the disease target of interest. Astex uses its knowledge of the 3-dimensional structure of the binding interaction between the compound and the target to design and grow from the initial fragment, adding further functionality to improve the binding interaction so that the final drug compound interacts optimally with the disease target – either through inhibition or activation.
In 2020, Astex and Taiho Pharmaceutical Co., Ltd. entered into a new partnership with Merck & Co., Inc., Kenilworth, New Jersey, USA (known as MSD outside the USA and Canada) through a subsidiary,[13] and this partnership was extended in 2021.[14]
Clinical pipeline
[edit]Astex has a pipeline of investigational compounds currently in various stages of clinical development.
Several compounds from drug discovery collaborations with Astex have been advanced by Astex’s biopharma partners into clinical trials and onto the market, including ribociclib (brand name “Kisqali”), a CDK4/CDK6 inhibitor discovered in collaboration with Novartis, subsequent to an original collaboration on FGFR inhibitors between Astex and Newcastle University, that was granted approval in the US and EU in 2017 for the treatment of breast cancer.[15] Erdafitinib (brand name “Balversa”) is an FGFR inhibitor that was discovered with Janssen Pharmaceuticals (a subsidiary of Johnson & Johnson), and received FDA market approval in 2019 for the treatment of adults with locally advanced or metastatic urothelial carcinoma with certain FGFR genetic alterations.[16] Capivasertib (brand name "Truqap") is an PKB/Akt inhibitor discovered and developed by AstraZeneca subsequent to its collaboration with Astex (and its collaboration with The Institute of Cancer Research (ICR) and Cancer Research Technology Limited). Truqap in combination with Faslodex received approval from the US FDA in 2023 for the treatment of adult patients with hormone receptor (HR)-positive, HER2-negative locally advanced or metastatic breast cancer with one or more biomarker alterations (PIK3CA, AKT1 or PTEN).
References
[edit]- ^ Tom Blundell: Director Archived January 1, 2015, at the Wayback Machine on OpenCorporates
- ^ Congreve, M; Murray, C. W.; Blundell, T. L. (2005). "Structural biology and drug discovery". Drug Discovery Today. 10 (13): 895–907. doi:10.1016/S1359-6446(05)03484-7. PMID 15993809.
- ^ Williams, P. A.; Cosme, J; Vinkovic, D. M.; Ward, A; Angove, H. C.; Day, P. J.; Vonrhein, C; Tickle, I. J.; Jhoti, H (2004). "Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone". Science. 305 (5684): 683–6. Bibcode:2004Sci...305..683W. doi:10.1126/science.1099736. PMID 15256616. S2CID 23149841.
- ^ Repasky, M. P.; Murphy, R. B.; Banks, J. L.; Greenwood, J. R.; Tubert-Brohman, I; Bhat, S; Friesner, R. A. (2012). "Docking performance of the glide program as evaluated on the Astex and DUD datasets: A complete set of glide SP results and selected results for a new scoring function integrating Water Map and glide". Journal of Computer-Aided Molecular Design. 26 (6): 787–99. Bibcode:2012JCAMD..26..787R. doi:10.1007/s10822-012-9575-9. PMID 22576241. S2CID 34803972.
- ^ Novikov, F. N.; Stroylov, V. S.; Zeifman, A. A.; Stroganov, O. V.; Kulkov, V; Chilov, G. G. (2012). "Lead Finder docking and virtual screening evaluation with Astex and DUD test sets". Journal of Computer-Aided Molecular Design. 26 (6): 725–35. Bibcode:2012JCAMD..26..725N. doi:10.1007/s10822-012-9549-y. PMID 22569592. S2CID 22123557.
- ^ Wolfson, W (2006). "Fragmentary solutions. Astex therapeutics puts the pieces together". Chemistry & Biology. 13 (8): 799–801. doi:10.1016/j.chembiol.2006.08.003. PMID 16931326.
- ^ Mountain, V (2003). "Astex, Structural Genomix, and Syrrx. I can see clearly now: Structural biology and drug discovery". Chemistry & Biology. 10 (2): 95–8. doi:10.1016/s1074-5521(03)00030-9. PMID 12618177.
- ^ Carr, R. A.; Congreve, M; Murray, C. W.; Rees, D. C. (2005). "Fragment-based lead discovery: Leads by design". Drug Discovery Today. 10 (14): 987–92. doi:10.1016/S1359-6446(05)03511-7. PMID 16023057.
- ^ "Japan's Otsuka to buy Astex Pharma for about $900 million: Nikkei". Reuters. 4 September 2013. Retrieved 14 April 2021.
- ^ "SuperGen to Merge with Astex for $25M in Cash". Genetic Engineering News. 7 April 2011. Retrieved 14 April 2021.
- ^ "SuperGen, Inc. Changes Name to Astex Pharmaceuticals, Inc., Announces New Stock Ticker Symbol and New Website". BusinessWire. 12 September 2011. Retrieved 14 April 2021.
- ^ "Fragment-based approaches to drug discovery" (PDF). Sp2. June 2006. Retrieved 25 March 2021.
- ^ Brackley, Paul (9 January 2020). "Astex Pharmaceuticals and Taiho Pharmaceutical sign cancer drug deal with Merck that could be worth $2.5 billion". Cambridge Independent. Retrieved 25 March 2021.
- ^ Brackley, Paul (21 January 2021). "Astex and Taiho strike further oncology licensing deal with MSD". Cambridge Independent. Retrieved 25 March 2021.
- ^ Broderick, Jason M (14 March 2017). "FDA Approves Kisqali for Breast Cancer Subset". Cure Today. Retrieved 25 March 2021.
- ^ "FDA grants accelerated approval to erdafitinib for metastatic urothelial carcinoma". U.S. Food and Drug Administration. 12 April 2019. Retrieved 14 April 2021.