The first "Jackass" film not to be endorsed by the Miller Brewing Company. The cast and crew refused to have alcohol on set to support Steve-O in his rehab process.
The Lamborghini Tooth Pull sequence was originally shot for Jackass Number Two (2006), with Vincent Margera getting his tooth pulled. A shot of it was featured in the original trailer, but was pulled from the final release due to Margera's 2006 sexual assault arrest. This time around, it was Ehren McGhehey getting his tooth pulled.
The film proved to be a real test for Steve-O in particular as this was the first Jackass movie he had made whilst sober. He had been clean for two years at the time of filming.
The intro to the movie was supposed to feature all the stars being hit in the head while being filmed with a super slow-mo camera, but Bam Margera could not participate after a woman assaulted him in the back of the head with a bat which caused internal bleeding. In the final intro, Margera is dressed up as a cupcake who gets hit on his body in slow motion and later using a paint ball gun.