Chan Zuckerberg Biohub Network

CellBio24 is less than one day away! Here are some opportunities to learn about what we’re up to at CZ Biohub. 💬 Sandra Schmid speaks at "The Future of Cell Biology" session | Talk title: "Cell Biology: The essential biomedical discipline" | Saturday, Dec. 14, 1:50 pm in Room 31B 📃 Teun Huijben presents “Ultrack: Large-scale versatile cell tracking under segmentation uncertainty” | Sunday, Dec. 15, 11:15 am, Board B513 📃Madhurya Sekhar presents “Building an automated, multimodal live-cell optical pooled screen platform" | Sunday, Dec. 15, 11:15 am, Board B543 📃Rodrigo Baltzar-Nunez presents “Global organelle profiling in human iPSCs reveals cellular and molecular changes in Alzheimer’s disease” |  Sunday, Dec. 15, 11:15 am, Board B419 💬Ziwen Liu speaks on “Generalized virtual staining of landmark organelles in diverse cell types and phase contrast methods” at the Organelles & Extracellular Vesicles Microsymposium, | Monday, Dec. 16, 10 am, Room 30C + poster immediately following at Board B51 📍 And come visit us at Booth # 119, with Chan Zuckerberg Initiative. Get demos of our tools for scientists! #CellBio2024 #CellBio24 #ASCB24 #cellbiology #microscopy #zebrafish #imaging

🔊 The results of the clinical study are in for the Remoscope – an AI-powered, low-cost device for diagnosing malaria! Tested on blood samples from more than 500 individuals in eastern Uganda, an area with a high rate of malaria transmission, it performed better than expected, and is on track to outperform the conventional diagnostic method in future studies, all without the need for manual labor or costly reagents. Remoscope can image and classify 2 million red blood cells in 12 minutes and give results in as little as 1 minute, compared to at least 45 minutes for the standard method. “The most important thing for treating malaria is knowing who has the parasite, and who doesn't, so accurate and fast diagnosis will help to quickly triage patients into appropriate treatment, instead of waiting potentially a day or more, when mosquitos can feed on that person and continue the cycle of infections,” says Biohub San Francisco President Joe DeRisi. “Rapid treatment is required to break the chain.” Read more ⤵️ https://lnkd.in/gt3MUB43 #InfectiousDisease #GlobalHealth #malaria

We’re looking forward to connecting with the #CellBiology community at American Society for Cell Biology (ASCB)'s Cell Bio 2024 in San Diego, CA! Check out our panel discussion to learn more about the exciting science happening across the CZ Biohub Network and Chan Zuckerberg Initiative. 📍And visit us at Booth #119! Get demos of our tools for scientists, including OpenCell, CellxGene, Zebrahub, Mantis, and Ultrack. #CellBio2024 #CellBio24 #ASCB24 #microscopy #zebrafish #imaging #virtualcell

The Inter-lab Confab is a key ingredient in the San Francisco Biohub’s “secret sauce”! Twice a year we bring together the community, including students, postdocs, and scientists from the labs of Biohub Investigators at our partner institutions, Stanford University, University of California, Berkeley, University of California, San Francisco, for an invigorating afternoon of science and sharing. Hear from these #CZBiohubSF Investigators and their students on why they love this event! 🧑🔬 María Díaz de León Derby, UC Berkeley/UCSF Bioengineering Ph.D. student (Fletcher Lab) 👨🔬 Dan Fletcher, Ph.D., D. Phil., UC Berkeley professor of Bioengineering 👩🔬 Jen Dionne, Ph.D., Stanford professor of Materials Science & Engineering 👨🔬 Jason Casar, Stanford Materials Science and Engineering Ph.D. student (Dionne Lab)

Single-cell transcriptomic atlases are providing substantial new insights into human biology, and Tabula Sapiens 2.0, a major expansion of a human cell atlas first published in 2022, marks a significant milestone. The original Tabula Sapiens included single-cell transcriptomic data from 24 different organs and tissues from a diverse set of donors. Tabula Sapiens 2.0 doubles both the total number of cells, and also the number of donors with multi-organ contributions; the latter increases the number of tissues and donors for which genetic background, age, sex, and epigenetic effects are controlled for. Comprising more than 1.1 million cells across 28 tissues from healthy donors aged 22 to 74 years, Tabula Sapiens 2.0 offers a comprehensive multiorgan dataset that enables systematic analysis of rare cell populations, while accounting for donor-specific variations. Accompanying the atlas, a new open-access web portal for analysis of the dataset with CELLxGENE will launch this week. The portal will incorporate ChatTS, a web-based tool leveraging a large language model, allowing the broader community to make clinically relevant queries into deidentified medical records for all donors represented in the dataset. To build the Tabula Sapiens, over the past eight years, teams of dozens of scientists at CZ Biohub San Francisco and partner institutions have created robust pipelines for single-cell sequencing of whole organisms from Drosophila to zebrafish to mice to humans. This work represents a landmark for human cell atlases. All data are freely available for the community to continue learning from and improving this reference atlas. Stephen Quake, D.Phil. Stanford University University of California, Berkeley University of California, San Francisco https://lnkd.in/gPtWymJ5

New in Science Magazine: a team of scientists led by Shana Kelley of CZ Biohub Chicago presents a nanoscale protein sensor for continuous, real-time tracking of inflammatory biomarkers in vivo, opening the door to similar devices for managing, preventing disease. Sensors of glucose, a small molecule, are revolutionizing diabetes care, but creating effective protein sensors has been a vexing problem in bioengineering. The Kelley team’s breakthrough enables real-time tracking of inflammatory proteins, opening the door to similar devices for disease detection and management. Read more ⤵️ https://lnkd.in/gSmYsWEu #CZBiohubCHI #science #inflammation #sensors

Congrats to Shalin Mehta, head of the Computational Microscopy group at CZ Biohub San Francisco, who has been named a 2024 Allen Distinguished Investigator! He is one of 14 scientists tapped to work on six projects investigating fundamental cellular functions. Mehta’s work integrates computational imaging and AI algorithms to reveal the structure and dynamics of tissues, cells, and organelles without stains. Read more about the awards from Allen Institute. https://lnkd.in/emy2DaHB

In a piece published today in Molecular Biology of the Cell, #CZBiohubSF Chief Science Officer Sandra Schmid (pictured) and scientists from Chan Zuckerberg Initiative write: “AI has the potential to revolutionize cell biology, and cell biologists will play an essential role in driving this revolution.” They further add that cell biologists' "unique appreciation for the complexity of cells and how they can confound us" will be indispensable in developing and validating models of cellular function. But in turn, “cell biologists will need to embrace high-throughput methods and employ best practices for the consistent management and open dissemination of, most importantly, interoperable data.” Co-authors are: Ambrose Carr, Jonah Cool, Theofanis Karaletsos, Donghui Li, PhD, Alan Lowe, Stephani Otte, and Sandra Schmid. Read the paper ⤵️ https://lnkd.in/gJ84ieGh #AI #CellBiology #science

The Rapid Response group of CZ Biohub San Francisco has worked with public health practitioners in more than 30 countries to build capacity for infectious disease outbreak response. Earlier this month they came together in New Orleans for two days of scientific presentations and practical workshops, with support from Chan Zuckerberg Initiative and Bill & Melinda Gates Foundation. Scientists from Southeast Asia, Latin America, and the African continent shared research findings on a variety of topics, including mpox, neuroinfections, arboviral disease, sepsis, and antimicrobial resistance. “It was great to bring together our grantee family to discuss science and reinforce our connection to each other as a global community, with the common goal of improving the quality of health of our local communities,” says Cristina Tato, director of the #CZBiohubSF Rapid Response group. Learn more about Biohub’s Rapid Response group: https://lnkd.in/gdnnyrKk #GlobalHealth #PublicHealth #metagenomics #InfectiousDisease

Acclaimed German filmmaker Werner Herzog–whose work has indelibly shaped cinema over a 50-year career–stopped by to speak with #CZBiohubSF Investigator Dmitri Petrov and colleague Katie Solari about how advanced genomic analyses can help wildlife conservation efforts. Petrov (pictured on right) and his team build genetic tools to track evolutionary adaptations and study what these changes can tell us about where a species came from and what its future might hold. As director of the Stanford Program for Conservation Genomics, he leads projects involving at-risk species like zebras, tigers, and rhinos. But his team also applies the lens of evolution to important questions about human health and disease, including how human microbiomes change over time and the role that certain mutations play in cancer growth. Check out Petrov’s new preprint on threats facing snow leopards. ⤵️ https://czi.co/3Z2jPKL