Corey John Bishop, Ph.D.

Congrats to Prof. Mohsen Akbari and his team from the Laboratory for Innovations in Micro Engineering (#LiME) and the Terasaki Institute for Biomedical Innovation (TIBI) for their latest article published in the Chemical Engineering Journal (CEJ). The article, entitled ‘’High-density culturing of the dermal fibroblast cells on hydrogel-based soft microcarriers for cell therapy application’’, focused on the role of dermal #fibroblasts in #cell #therapy, particularly in tissue repair and regeneration. The group addressed the challenge of scaling up dermal fibroblast production by optimizing their smart microcarrier, Cytogel, for efficient cell expansion. The new formulation demonstrated over 90% cell attachment and 60% thermal detachment efficiency, with superior CD90 expression and collagen production. This approach shows significant promise for industrial-scale cell culture in cell therapeutic applications. We are glad to see that the #ElastoSensBio was instrumental in characterizing the mechanical properties of #GelMA, ensuring robust and precise results. Read the full article here: https://lnkd.in/e4tBBxhi #Research #CellTherapy #Hydrogel #Microcarriers #Biotechnology #LiME #BiomedicalInnovations #LifeSciences

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Our collaborative review article reached 20 citations Achieved on October 18, 2024 Article: Stimuli-Responsive Polymers for Transdermal, Transmucosal and Ocular Drug Delivery DOI: 10.3390/pharmaceutics13122050 Intravenous infusions of medications are invasive, painful and stressful for patients and carry the risk of infections, tissue damage and other adverse reactions. In order to account for these disadvantages, alternative routes of drug delivery, such as transdermal, nasal, oromucosal, ocular and others, have been considered. Moreover, drug formulations have been modified in order to improve their storage stability, solubility, absorption and safety. Recently, stimuli-responsive polymers have been shown to achieve controlled release and enhance the bioavailability of multiple drugs. In this review, we discuss the most up-to-date use of stimuli-responsive materials in order to optimize the delivery of medications that are unstable to pH or undergo primary metabolism via transdermal, nasal, oromucosal and ocular routes. #SU #drugdelivery #review

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Hyaluronic Acid-Based Wound Dressings… Read our latest publication in Iranian Journal of Polymer Science and Technology (IJPST)!! Many thanks to Dr. Hamed Daemi for supervising this team to publish this review article in the project of the National Elite Foundation #بنیاد_ملی_نخبگان #Iranian Journal of Polymer Science and Technology (IJPST) #hyaluronic_acid #wound_dressings

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https://lnkd.in/dXC8VJK [Cu(OH)·TMEDA]2Cl2 catalyzes an intermolecular coupling of arylboronic acids with imidazoles.

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what model of HPLC with a UV-vis detector is most suitable for undergraduate analytical teaching labs?

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New article with my Iranian colleagues on improving the performance of electrospun nanofibers using different cross linking methods: "Advances and applications of crosslinked electrospun biomacromolecular nanofibers Link: https://lnkd.in/eywWzSc2

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https://lnkd.in/emYYigqr Organophotoredox catalysis for an intermolecular hydroaminoalkylation (HAA) of styrenes with unprotected primary alkylamines

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https://lnkd.in/gkACZA7 The combination of ZnI2 and DMAP catalyzes a mild cyclization reaction of propargylic N-hydroxylamines

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💖 #𝐍𝐞𝐰𝐒𝐩𝐞𝐜𝐢𝐚𝐥𝐈𝐬𝐬𝐮𝐞 | Functional Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine #mdpimaterials #NewspecialIssue 📢 Our newly announced Special Issue Edited by Prof. Ziyad S. Haidar 🔗https://lnkd.in/g3Ns6HyD 📝 Welcome to click and submit your manuscript！

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https://lnkd.in/ePe37_nt Douglass features The Liu/Qin Synthesis of Cyclopamine

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In our review paper, titled "Polymeric Micelles for Ocular Drug Delivery", which was recently published in “Molecular Pharmaceutics”, we discussed the challenges and advancements in delivering drugs to the eye. We explored the intricate barriers that impede effective drug absorption and distribution into the ocular tissues, and how polymeric micelles (PMs) offer a promising solution. PMs can solubilize hydrophobic drugs and maintain nanoscopic diameters without obstructing vision. We covered the latest R&D efforts reported on single or mixed micelles, copolymers, and gel systems, highlighting their benefits in enhancing drug release, residence time, and ocular bioavailability. The review emphasizes the significant preclinical and clinical progress in micellar ocular delivery systems, which led to the first nanomicallar formulation approved for clinical use by the US FDA (marketed as Cequa by Sun Pharmaceuticals). Check out the full article here: [Polymeric Micelles for Ocular Drug Delivery](https://lnkd.in/dNQYMdCU). #PharmaceuticalResearch #OcularDrugDelivery #Nanotechnology #PolymericMicelles #MedicalAdvancements

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https://lnkd.in/eD2mi-Pp Molecular iodine catalyzes practical and mild syntheses of substituted pyrans and furans under solvent-free conditions

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https://lnkd.in/ed55pQhm A catalyst- and solvent-free, three-component synthesis of tetrasubstituted pyrroles in very good yields

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Congratulations to the team Hailong Chen, Zhantao Liu (GaTech), Jue Liu (ORNL), Shuo Wang for achieving the world-record high conductivity in halide solid electrolyte! Our computation based on the Density of Atomistic States (DOAS) has revealed the mechanisms and promises of mixed anion systems in achieving high ionic conductivity https://lnkd.in/eNnddyPY

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https://lnkd.in/dpPZJ7k An iron-catalyzed radical alkylazidation of electron-deficient alkenes with trimethylsilyl azide and alkyl diacyl peroxides

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NIR Spectroscopy for Green and Sustainable Chemistry 🌱 As industries strive to minimize environmental impact, Near-Infrared (NIR) spectroscopy has emerged as a valuable tool in green chemistry. NIR’s ability to provide rapid, non-destructive analysis of chemical compositions without the need for solvents or complex sample preparation significantly reduces chemical waste. This aligns with the core principles of sustainability and resource efficiency 🌱 #GreenChemistry, #Sustainability, #NIR

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https://lnkd.in/dR5CX3B A chiral bisphosphine dioxide catalyzes an asymmetric conjugate reduction of acyclic β,β-disubstituted α,β-unsaturated ketones

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https://lnkd.in/guiBF4p A mild, aerobic, catalytic synthesis of nitriles directly from alcohols and aqueous ammonia

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22nd Iranian Chemistry Congress. The title of my article is the application of polyvinyl alcohol nanofibers in the preparation of wound dressings with the ability of controlled release of diabetic drugs with a green and harmless crosslinker for the skin and release control using porous metal nanoparticles.

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