Menlo Park, California, United States Contact Info
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• Preclinical drug discovery & development, drug-drug interaction (DDI), drug…

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Experience & Education

  • Amgen

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Volunteer Experience

  • Lab Manager

    UCSF

    - 3 years 10 months

    Science and Technology

    * Responsible for managing the daily operations of the lab
    * Oversees laboratory safety and ensures that laboratory in compliance with all regulations
    * Ensures all reagents and supplies are available when needed.
    * Manages and updates Chemical inventories and/or Risk Group Agent inventories.
    * Communicates and enforces laboratory safety rules to internal and external researchers working
    in the lab.

Publications

  • Transporter-mediated drug-drug interactions: regulatory guidelines, in vitro and in vivo methodologies and translation, special populations, and the blood-brain barrier.

    Drug Metab Rev.

    Russell LE, Yadav J, Maldonato BJ, Chien HC, Zou L, Vergara AG, Villavicencio EG.

    See publication

  • Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

    Nature Communications

    Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM.

    See publication

  • Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools

    Nat Chem Biol PMID: 37474759

    Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R

    See publication

  • Transporters and Toxicity: Insights from the International Transporter Consortium Workshop 4

    Clin Pharmacol Ther. PMID: 35546260

    Hafey MJ, Aleksunes LM, Bridges CC, Brouwer KR, Chien HC, Leslie EM, Hu SY, Li Y, Shen JS, Sparreboom A, Sprowl J, Tweedie D, Lai YR

  • The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake

    ChemMedChem 16(5):869-880 PMID: 33230949

    Venteicher B, Merklin K, Ngo HX, Chien HC, Hutchinson K, Campbell J, Way H, Griffith J, Alvarado C, Chandra S, Hill E, Schlessinger A, Thomas AA.

  • Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies

    FASEB Journal

    Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML & Giacomini KM

  • Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

    Proc Natl Acad Sci

    Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ.

  • Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies

    PLoS Genet.

    Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, Borselan M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B and Giacomini KM.

  • L-type amino acid transporter 1 activity of 1, 2, 3-triazolyl analogs of L-histidine and L-tryptophan

    Bioorg Med Chem Lett.

    Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA

  • Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

    J Med Chem. 2018 Jul 26

    Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA.

  • Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

    Mol Pharmacol. 2018 Jul ; 94(1):689-699

    Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM.

  • Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content

    PLoS Biol. 2018 Apr 16;16(4):e2002907

    Liang X., Yee SW., Chien HC., Chen EC., Luo Q., Zou L., Piao M., Mifune A., Chen L., Calvert ME., King S., Norheim F., Abad J., Krauss RM., Giacomini KM

  • Mutations in the fourth β-propeller domain of LRP4 are associated with isolated syndactyly with fusion of the third and fourth fingers

    Hum Mutat 2018 Jun;39(6):811-815.

    Sukenik HR, Chien HC, Heinz B, Bamshad MJ, Nickerson DA; University of Washington Center for Mendelian Genomics, Kircher M, Ahituv N

  • Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants: The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity

    John Wiley & Sons : Vol. 1 Chapter 2

    Giacomini KM & Chien HC

    See publication

  • A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568

    Science 356 (6339):757-759

    Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun MA, Wolf G, Baker M, Chien HC, Lai KN, Cheng X, Shen CJ, Macfarlan TS.

  • Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1)

    J Med Chem. 60(7):2685-2696 PMID: 28230985

    Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM.

  • LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.

    Bioorg Med Chem Lett. 26(20):5000-5006 PMID: 27624080

    Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA

  • Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

    Nat Genet. 48(9):1055-9 PMID: 27500523

    Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RH, Stehouwer CD, Logie L; MetGen Investigators.; DPP Investigators.; ACCORD Investigators., Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner…

    Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RH, Stehouwer CD, Logie L; MetGen Investigators.; DPP Investigators.; ACCORD Investigators., Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CN, Florez JC, Giacomini KM, Pearson ER

  • LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs

    Bioorg Med Chem Lett.PMID: 27106710

    Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA.

  • Rapid Method to Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in OCT1-transfected HEK Cells

    Drug Metab Dispos. PMID : 26700958

    Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM.

    See publication

  • Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

    Mol. Pharmaceutics PMID: 26528626

    Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM.

  • Prediction and validation of enzyme and transporter off-targets for metformin

    J Pharmacokinet Pharmacodyn. PMID: 26335661

    Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM.

    See publication

  • A long noncoding RNA protects the heart from pathological hypertrophy

    Nature 514(7520):102-6 PMID: 25119045

    Han P, Li W, Lin CH, Yang J, Shang C, Nurnberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien HC, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HS, Quertermous T, Chang CP.

  • OCT1 is a high-capacity thiamin transporter that regulates hepatic steatosis and is a target of metformin

    Proc Natl Acad Sci U S A. PMID: 24961373

    Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM.

  • Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage

    PLoS ONE 7(10):e47481 PMID: 23071813

    Chien HC, Wang HY, Su YN, Lai KY, Lu LC, Chen PC, Tsai SF, Wu CI, Hsieh WS, Shen CK.

  • Rate of evolution in brain-expressed genes in humans and other primates

    PLoS Biol 5(2): e13. PMID: 17194215

    Wang HY, Chien HC, Osada N, Hashimoto K, Sugano S, Gojobori T, Chou CK, Tsai SF, Wu CI, Shen CK.

Projects

  • Pfizer & UCSF: Uptake Transporters : Enabling Asymmetric Tissue Distribution

    -

    Other creators

  • Pfizer-CTI & UCSF : OCT1 antagonist mAb Program

    -

    Other creators

Languages

  • English

    Professional working proficiency

  • Chinese

    Native or bilingual proficiency

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