Smit Naik

The (Healthcare) Ground Beneath Our Feet… This year it is likely that over $10 billion will be invested in the digital health sector – a robust amount, no doubt, but inconsequential when compared to the amount of capital tied up in healthcare real estate assets, which is estimated to be $1.2 trillion by Jones Lang Lasalle. Of that amount, approximately $790 billion is in the hospital sector while the remaining $490 billion is in medical office assets. It is estimated that there are 48.6k facilities with 3.4 billion square feet of healthcare real estate, 42% of which are owned by REITs and another 33% held by other private investment vehicles. Much of the digital health investment is meant to make the physical healthcare infrastructure more productive: greater operating efficiencies, greater patient throughput, more relevant personalized care models with better outcomes. As the healthcare system is being pushed to be more distributed to lower cost sites of care, accelerated now by the rapid proliferation of automation and AI capabilities, the potential impact on healthcare infrastructure assets will be profound. Thoughts on what that might look like... https://lnkd.in/eTfAdUbS #digitalhealth Flare Capital Partners

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🚀 Healthcare investing: Not for the faint of heart, but for the visionaries who dare to change the world! 💡 Why it's unique: 🔄 Pivoting isn't just costly—it's potentially catastrophic 📊 Metrics as complex and sub-sector specific 🌐 A delicate ecosystem of stakeholders tugging in different directions 😃 But get it right, and you might just revolutionize healthcare while reaping substantial returns. 💰🏥

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Happy to jump back into another episode of the Innovation Wave podcast. On this episode, Bob McGriff and I discuss the current state of the life sciences ecosystem through the halfway point of 2024. We offer thoughts and analysis of what to expect for the remainder of the year. It's still a case of survive to '25'. #LifeSciences #Innovation #Healthcare #VentureCapital

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To my amazing network - I am thrilled to announce the launch of Pave Health Ventures, an early-stage venture fund dedicated to broadening access to healthcare and improving the overall well-being of our communities. I’ve been very fortunate in my healthcare career. As the Founder & CEO of MedPilot, we capped off a seven-year journey with a successful exit when we were acquired by Vytalize Health. For the last three years, serving as Chief Innovation Officer, I’ve had the honor to contribute to the remarkable growth at Vytalize, impacting the lives of hundreds of thousands of patients by enhancing the quality of care they receive. I am immensely grateful to Matt Buder Shapiro, not only for being the perfect partner and co-founder but also for being an incredible friend. Additionally, I extend my heartfelt appreciation to Faris Ghawi, Amer Alnajar, and Jordan Brown for their outstanding leadership and for broadening my perspective on the significance of value-based care. This journey has not only provided me with industry expertise but has allowed me to cultivate invaluable relationships and an incredible network. As I embark on this new chapter, I am profoundly grateful to be supported by top executives and thought leaders in the investment, wellness, and healthcare industries. Within the healthcare ecosystem, we are represented by key stakeholders from health systems, insurers, governmental organizations, retail health businesses, provider groups, and value-based care organizations. At Pave Health Ventures, we believe the timing couldn't be more opportune to help support health-focused startups. With the growing prevalence of illness and chronic health conditions impacting our communities, consumers and key Healthcare Stakeholders are increasingly prioritizing proactive and preventative care. This shift in focus is fueling demand for technology, products, and services aimed at improving health outcomes, unlocking trillions of dollars in growth potential within the healthcare landscape. Pave Health Ventures is all-in. We are actively seeking solutions that tackle the root causes of illness, manage chronic conditions, and optimize care and care teams. Please support us in our mission by opening your networks and introducing us to amazing founders and entrepreneurs. Together, let's help pave the way to a healthier tomorrow. Jacob Myers

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⛳ Emerging fund managers pulse check. PitchBook tracks over 10,000 funds that are raising money, with 45% being emerging fund managers (defined as firms with less than 3 funds). Despite a dip in available capital—down to 16% from the pre-pandemic 23%—these managers are finding creative ways to stay competitive, like partnering with larger firms. 💼 Joanna Drake (founder turned investor) shared how "wildly different" it is raising a fund versus for a startup. One key datapoint she shared on the fund side was how little feedback you get along the way (and the years you can wait for it). The “long-winded and challenging process to raise capital” inspired Drake and Ben Black to create RAISE Global, a community for emerging fund managers and the “forward-thinking LPs” who back them. (A decade later, several hundred emerging managers with AUM under $200m are on the platform) They've found the newest emerging managers are more diverse and geographically dispersed than Silicon valley, and more were able to crack the ceiling and raise larger $100m funds (although this is still a small % of the market, requiring partnership with larger funds at the late stage). ▶ And not a hugely surprising datapoint: A lot of action is in the sub $49 million range, where roughly 50% of emerging managers are raising. Theresa Sorrentino Hajer, Head of U.S. venture capital research at Cambridge Associates warns that past success isn't actually a strong indicator on it's own to assess emerging managers. We've had a valuation reset. And newer managers with investments during the 2019-2021 "party days", need to build relevant track record and play to their strengths. A lot of emerging managers are specializing (70% who applied for Raise had a thematic focus), and betting on getting in as early as possible in the startup's lifecycle (Raise: 31% at accelerator/ pre-seed stages, and 47% at seed stage). “Emerging managers have to compete on a different dimension,” Nick Moran from New Stack Ventures. You're no longer just dealing with capital. Emerging VC's need to be as innovative and nimble as the startups they invest in, having a unique thesis and insights. They also play a role at the top of the deal-flow funnel: helping larger firms find promising companies, so finding a thesis, sector or philosophy aligned partner at a larger firm is helpful. Onwards! #EmergingManager #Startups #VC

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#hiring If anyone knows an awesome engineer that would be interested in joining an emerging #AI company doing important work in #healthcare, please drop me a line! Andy AI is backed by General Catalyst, YCombinator, Greater Ventures, and others, and they’re looking to hire a full stack engineer (US based) who's excited about using AI to improve healthcare and reduce nurse burnout. Andy is AI software that automates clinical documentation for nurses who do home visits. A nurse makes an audio recording of the visit and Andy automatically generates a form that usually takes nurses 90 minutes to complete. Nurses love the product because it potentially saves them 15 hours of charting a week! The founders previously built healthcare AI at Google Health and Apple, and are now building their vision to transform home health. More about Andy AI: https://with-andy.com/ Nurses love it: https://lnkd.in/g9XqZrUq #GenAI #digitalhealth #hiring #engineers #healthtech

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🧬 This week's Austin Bio & Health Roundup brings new capital to deploy, fresh data, major clinical milestones, & important strategic acquisitions. 🧬 💰 Funding Arsenal Bridge Ventures is raising $150M to build bio startups. Based in Austin and New York, their explicit aim is to fuel emerging science beyond “traditional” hubs. More fuel for the Austin Bio & Health flywheel. Huge congrats Jim Graham CFA. I am very excited to see what’s to come. 📊 Data New data from Peter Walker at Carta breaks down median dilution & pre-money valuation for seed-stage companies by sector in 2024. For Bio & Health, the answer is...It depends. Biotech saw median dilution at 25.5%, the most of any sector, while Healthtech ranked 12th with 19.8%. Their pre-money valuations were quite similar, both just under $12M, putting them on the lower end for this stage compared to other sectors. Got to pump those numbers up!! 🚀 Launches, Expansions, Milestones, and Wins Somite Therapeutics, the AI driven cell therapy company, has been granted FDA Orphan Drug and Rare Pediatric Disease Designations for their lead program in Duchenne muscular dystrophy. At this rate, I may need to a create Somite section in the roundup! Amazing Micha Y. Breakstone 🇮🇱🎗️! Neuralink received Breakthrough Device Designation from the FDA for Blindsight. And yes, it’s exactly what it sounds like! 🤝 M&A and Partnerships SubjectWell, a patient recruitment platform, is acquiring Trials24, a provider of patient recruitment solutions with a strong footprint in 13 European countries. Congrats Fred Martin on the next steps to building a truly global company. What’s Next?

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Couple of weeks ago had the pleasure of sharing my story to Alexander Benkendorf about starting CastPrint and later moving on to join Verge HealthTech Fund and the learning along the way. Some topics we discussed: 💡What does it take to bring innvation in healthcare 💡How did my startup background help me better prepare for VC work 💡How founders can better engage with VCs and what are the tips and tricks from the "other side" Thanks Alexander for having me!

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Some VC investors believe that brick and mortar - referring to a physical presence of some kind - should be avoided at all costs. Yet, the track record of clinic and hybrid care businesses in health care indicates otherwise. ==> One Medical (sold for $3.9 billion to Amazon), Oak Street (bought by CVS for $10.6 billion), Lifestance (IPO at $7.5 billion market cap), and PE-backed Premise Health (acquired by OMERS Private Equity for $1.1 billion) If a clinic is indicated as the optimal way to deliver care for that patient population, there are creative ways to build and operate them. Full article below with advice and strategies on how to build and operate hybrid clinics from my teammate Anarghya Vardhana from Maveron, Amir Dan Rubin from OneMedical Group, Steven Eidelman from Modern Animal and more!

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I used to think LPs only invested in emerging VC / PE firms for better returns. That’s true…sort of They obviously first and foremost want high returns, but in building our firm and studying the industry I’ve learned that LP motivations are more nuanced than that To understand why an LP really might invest in us, I start with the assumption that they could invest that $ in Blackstone (or a similar large PE firm with top quartile track record) What could we offer that is incremental, and how should we position ourselves in that way? 1. Smaller funds can be higher upside — LPs may be looking for higher risk / higher return opportunities, so we have to emphasize the path to outlier returns. This means discussing not only their expected value but also the distribution of outcomes, and how that might differ from the rest of their portfolio 2. Harder to partner with successful firms later — LPs are often looking to build long-term partnerships with firms that will be around for many fund cycles, and that is about more than just returns. It’s important to emphasize not just the strategy of this fund but also the vision of the firm we’re building 3. Co-invest opportunities — Some LPs don’t care about co-invest, others only invest in funds for co-invest. When speaking with the latter, we emphasize that we have a disciplined and repeatable process to generate and share co-invest opportunities (easy to say, harder to execute) 4. Learning and thought partnership — We have LPs that invested in us because they have conviction in or personal passion for health & wellness and want to learn more about the ecosystem. For these folks we might talk through investment opportunities they see that are in our industry, or invite them to industry events. We also spend a ton of time writing quarterly letters to help them track the industry and learn from our companies It takes years to know where our returns will ultimately shake out, and we’ll have no reason or permission to exist if they aren’t good In the meantime it’s crucial to recognize and deliver on these other needs of our LPs, to provide the experience that they signed up for

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Summary: A settlement agreement has been reached between Venture capital firm Fearless Fund and the American Alliance for Equal Rights, resulting in the shutting down of Fearless Fund's Strivers Grant program. The program was initially developed to provide funding for small businesses owned by Black women, but faced a lawsuit for alleged discrimination against non-Black founders. Key takeaways: The Fearless Fund's program has been shut down due to a lawsuit from AAER claiming it discriminated against non-Black founders. The fear of legal repercussions has resulted in the Fearless Fund losing partnerships and shifting focus away from initiatives benefiting minorities. Despite the settlement, Fearless Fund remains committed to helping under-resourced entrepreneurs. Counter arguments: Some argue that using the Civil Rights Act of 1866, intended to help the formerly enslaved, against a program benefitting Black entrepreneurs is ironic and counterproductive. The shutting down of the program is a blow to the diversity, equity, and inclusion movement, as companies continue to struggle with addressing disparities in funding and opportunities for minority groups.

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These VC firms have fresh capital and are eager to deploy. 🔴 Olivia Wilde launched her new VC firm, Proximity Ventures, with Neil Sirni, Jason Mack, and Santi White. The firm expects to hold a close next month and will invest in consumer and enterprise sectors. 🔴 Greenwich based Tamarack Global closed its $72M Opportunities II fund to focus on energy transition, defense-tech, the space economy, robotics & automation, AI, and more. 🔴 New York based BBG Ventures raised a $60M fund to support diverse founders. 🔴 Los Angeles based MaC Venture Capital raised its third $150M fund to back diverse founders and industries such as aerospace, enterprise software, fintech, health tech, and defense, among others. 🔴 Lisbon based Faber closed its €31 million Faber Tech III fund to support early stage innovation in Southern Europe. 🔴 Chicago based Listen Ventures is planning to raise $75M for its fourth fund to back consumer-obsessed founders building brands at the tipping point of behavior shifts. 🔴 Mumbai based Inflexor Ventures closed its first ₹350 crore Opportunities Fund to support its existing portfolio companies. 🔴 France based Axeleo Capital closed its new €125M greentech fund. 🔴 Singapore’s Nanyang Technological University (NTU) partnered with venture capital firm Walden International to establish a new VC fund, Nanyang Frontier Fund. The fund is looking to raise $37.9M to back deep tech spin-offs from the university.

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Abby Levy talks about venture's role in US healthcare and what we can expect to see as technology impacts the space on TFR. Check out the rest of the conversation with Abby & Alan Patricof of Primetime Partners on Episode 433.

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🧬 This week's Austin Bio & Health Roundup features nearly $200M in funding & new capital, M&A, more infrastructure coming, & hopefully an opening of the Texas Bio & Health IPO window🧬 💰 Funding Function Health has closed its Series A, securing $53M in total funding. Function’s platform offers 100+ tests for $499 per year, focusing on prevention and empowerment. The round was led by a16z Bio + Health and includes several celebrity investors. Congrats to Mark Hyman, MD, Pranitha Patil, Jonathan Swerdlin, Mike Nemke, Seth Weisfeld, and Dan Swerdlin. Sensi.AI raised a $31M Series B led by Insight Partners and Zeev Ventures to enhance its 24/7 monitoring technology for seniors and home care. Way to go Romi Gubes and the entire team! Ironspring Ventures raised $100M for their second fund, focusing on “manufacturing, construction, transportation, and energy.” Exciting times for Ty Findley, Adam Bridgman, Peter J. Holt, and the expanding Ironspring team! Now, why include this in a Bio & Health newsletter? I believe there will be a value migration from drugs, devices, and diagnostics to the bio innovation tech stack itself. One key area of that stack is biomanufacturing. As new modalities like cell and gene therapy rise, the challenge of scaling these therapies presents a significant opportunity for innovation. While as far as I know Ironspring hasn't invested in this subsector yet, I look forward to seeing what they do with Fund 2. 🤝 M&A and Partnerships Significo, a software development that builds healthcare apps and solutions, acquired Bunch, an AI leadership coach app. Congrats to Rick McCartney and team! 🚀Launches, Expansions, and Milestones BrainCheck, a cognitive assessment software platform, announced their adoption by the Physicians Hearing Network (PHN), bringing insights to 270 members across 12 states.  Keep up the momentum Kim Rodriguez and team! 🏗️ Infrastructure Texas State University is partnering with Concept Companies to build a life sciences incubator at their round rock campus. The incubator will have labs, offices, admin support, and collaboration spaces. The teams hope to complete construction by the end of 2025. DES Architects + Engineers opened a new office in Austin, aiming to bring their expertise to the city’s burgeoning life science market. Welcome Kevin D. Norman, Tracy Wong, and the rest of the DES team! 🚩 Texas Bio Triangle Fort Worth-based biopharma company Actuate Therapeutics, Inc. is preparing for an IPO, targeting a raise of about $50M. What’s Next? #AustinNext #LifeSciences #Healthcare #Biotechnology

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Heading to HLTH USA 2024? Join me on 10/22 for a panel titled "Consumer Wellness Means Business," where we'll discuss the early-stage investment climate, consumer priorities and trends that will lead us into 2025 and beyond. I look forward to sharing this discussion with Cathy Friedman of GV (Google Ventures), Amanda Eilian of Able Partners & Scott Barclay of Insight Partners. See you there! #HLTHUSA #HLTH #healthcareinnovation

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Crunchbase charted smaller VC funds that successfully raised capital this year. Joanna Glasner, A few callouts: 🏁"Smaller" funds (sub $500 million!) have reached the lowest raised tally in years: totaling $13.7 billion.. For context and as charted: $40 billion was raised in 2022. 🏁Larger round sizes are getting larger, i.e. OpenAI - clearly favoring funds with deeper pockets. However: smaller funds are driving the #alpha, are able to put smaller sums to work in transformational companies, and deliver returns without requiring #unicorn exits. 🏁History has shown that funds that are raised in sluggish environments tend to outperform. Accel and Andreessen Horowitz #VentureCapital #Fundraising

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I'm so excited to continue supporting Prolific Machines, Inc., and the incredible Deniz Kent, PhD ,Max Huisman, and Declan Jones. Today's cellular biology processes are incredibly expensive, inefficient, imprecise, and sometimes purely ineffective. These processes are used from everything from making antibodies to treat diseases, to fermentation used to make high-value nutritional proteins in baby formula, to whole cuts of cultured meat. Prolific has developed a biology platform that leverages light to guide cell behavior and optimize performance over time using AI. By combining light, bioengineering, hardware, and AI in fundamentally new ways, Prolific can help pharmaceutical, nutritional, and therapeutics companies get to market faster, less expensively, and more efficiently — ultimately in hopes of helping improve outcomes — a mission any of us can get behind. Mark Cuban Peter T. Frederick Blackford Cooper Rinzler David Adelman Darco Capital Breakthrough Energy Michael Schulson Kevin Love Tobias Harris Breyer Capital Charles Besser Brennan Besser Lettuce Entertain You Restaurants https://lnkd.in/ea2TqdQk

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We took the pulse of emerging fund managers about what it's been like for them during these post-ZERP, venture-capital-winter years. #venturecapital #veteranventures

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"More than $12.5 billion has been bet on digital behavioral health in the last five years, according to Rock Health. Funding peaked in 2021, with $5.7 billion spent that year alone." As investors and innovators, I believe we need to broaden our focus in the behavioral health space from just expanding access to care, to effectively measuring the quality of that care. As we continue to encourage individuals, employers and plans to increase their spending and focus on behavioral health, we need reliable tools for measuring the long-term efficacy and impact of behavioral health services.

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