National Library of Medicine (NLM)’s Post

One year ago, Katalin Karikó, PhD, and Drew Weissman, MD, PhD,cwere the recipients of the 2023 Nobel Prize in Physiology or Medicine. Today the Penn Institute for RNA Innovation, led by Weissman, bustles with individuals in crisp white lab coats carrying vials of carefully mixed compounds. They are some of the world’s foremost medical experts and the sharpest young investigators, both eager to add to Karikó and Weissman’s monumental research and to bring RNA innovation to new areas of research. #pennmedicine #nobelprize #mRNA Learn more: https://lnkd.in/etmYPzty

As the year ends, we’re reflecting on the compelling research that St. Jude scientists accomplished this year. In our latest 2024 #ResearchWrapUp, we’re highlighting advances in molecular biology. Throughout the year, St. Jude researchers leveraged cutting-edge techniques to uncover critical insights into cellular processes. Highlights include using structural biology to guide drug discovery for conditions including gout, identifying unique mechanisms behind ultrafast neurotransmission, and revealing how the primary cilium or “cell antenna” is structurally maintained. These discoveries connect fundamental molecular mechanisms to real-world health challenges, providing a path toward novel therapies. The work also reaffirms St. Jude as a leader in using molecular biology to improve outcomes for children worldwide. Swipe to see this year’s discoveries in molecular biology. #ResearchWrapUp #MolecularBiology #StJude #YearInReview #ChildhoodCancer

New issue alert! 📢 The June issue of Molecular Imaging and Biology (MIB), guest edited by Mrignayani Kotecha, PhD and Marty Pagel, is a collection on "EPR Imaging and Application to Biomedical Sciences: On the 80th Anniversary of the Discovery of EPR". Dive into the latest advancements in this field as we celebrate eight decades since the discovery of EPR! Full lineup: https://lnkd.in/grJMghW5

We are thrilled to invite all Molecular Biologists, Neuroscientists & Bioinformatics Experts to join us at the STOC General Meeting taking place on the 8-9 July 2024 in Singapore! The SpatioTemporal Omics Consortium (STOC), is a scientific community focused on using spatially resolved omics technologies to map and understand all living things. During this event, Jan Mulder from Karolinska Institut will conduct a 60-minute workshop on Establishing the Standards and Community for Massive Integrative Brain Atlas Projects. Key takeaways from the workshop include: • Defining the gaps and needs in large-scale brain mapping initiatives. • Addressing the unique challenges of neuroscience-related data integration. • Identifying opportunities to leverage this collaborative approach for groundbreaking discoveries in brain function, evolution, development, and disease. Additionally, Jan Mulder will also co-lead a roundtable discussion focused on Data Access and Sharing, together with Ido Amit from the Weizmann Institute of Science and Xun Xu from BGI-Research. Registration is required and we are open for poster abstract submission now until the 21st June 2024. We look forward to seeing you there! 🔗 https://lnkd.in/gvV7iJuQ #STOC2024 #spatiotemporalomics #cellulargenomics #spatiotemporalbiology #singlecellanalysis #globalcollaboration #Singapore #meetings #breakthroughscience #science #virtual

Why is ICMS® worth going to year after year? Here’s a word of advice from  Geoffrey W. Abbott, Professor, Physiology & Biophysics at University of California: "𝗜 𝗮𝘁𝘁𝗲𝗻𝗱 𝗮𝘀 𝗺𝗮𝗻𝘆 𝗜𝗖𝗠𝗦 𝘀𝘆𝗺𝗽𝗼𝘀𝗶𝗮 𝗮𝘀 𝗽𝗼𝘀𝘀𝗶𝗯𝗹𝗲 𝗯𝗲𝗰𝗮𝘂𝘀𝗲 𝘁𝗵𝗲𝘆 𝗼𝗳𝗳𝗲𝗿 𝗮 𝘂𝗻𝗶𝗾𝘂𝗲 𝗰𝗵𝗮𝗻𝗰𝗲 𝘁𝗼 𝗻𝗲𝘁𝘄𝗼𝗿𝗸 𝘄𝗶𝘁𝗵 𝗱𝗶𝘃𝗲𝗿𝘀𝗲 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀 𝗶𝗻 𝗮 𝗳𝗿𝗶𝗲𝗻𝗱𝗹𝘆, 𝘀𝘁𝗶𝗺𝘂𝗹𝗮𝘁𝗶𝗻𝗴 𝗲𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁. 𝗪𝗶𝘁𝗵 𝗳𝗲𝘄𝗲𝗿 𝘁𝗵𝗮𝗻 𝟭𝟱𝟬 𝗮𝘁𝘁𝗲𝗻𝗱𝗲𝗲𝘀, 𝗲𝗮𝗰𝗵 𝘀𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺 𝗽𝗿𝗲𝘀𝗲𝗻𝘁𝘀 𝗮 𝘄𝗲𝗹𝗹-𝗰𝘂𝗿𝗮𝘁𝗲𝗱 𝘀𝗲𝗹𝗲𝗰𝘁𝗶𝗼𝗻 𝗼𝗳 𝗽𝗿𝗲𝘀𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻𝘀, 𝗯𝗿𝗶𝗻𝗴𝗶𝗻𝗴 𝘁𝗼𝗴𝗲𝘁𝗵𝗲𝗿 𝗲𝘅𝗽𝗲𝗿𝘁𝘀 𝗳𝗿𝗼𝗺 𝘃𝗮𝗿𝗶𝗼𝘂𝘀 𝗱𝗶𝘀𝗰𝗶𝗽𝗹𝗶𝗻𝗲𝘀 𝗮𝗻𝗱 𝗯𝗮𝗰𝗸𝗴𝗿𝗼𝘂𝗻𝗱𝘀. 𝗧𝗵𝗲𝘀𝗲 𝗲𝘃𝗲𝗻𝘁𝘀 𝗳𝗼𝘀𝘁𝗲𝗿 𝗻𝗲𝘄 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗻𝗱 𝗳𝗿𝗶𝗲𝗻𝗱𝘀𝗵𝗶𝗽𝘀, 𝘄𝗶𝘁𝗵 𝗽𝗿𝗼𝗴𝗿𝗮𝗺𝘀 𝘂𝗻𝗶𝘁𝗶𝗻𝗴 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁 𝗮𝗿𝗲𝗮𝘀 𝗼𝗳 𝗶𝗼𝗻 𝗰𝗵𝗮𝗻𝗻𝗲𝗹 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵. 𝗕𝗲𝘆𝗼𝗻𝗱 𝘀𝗲𝘀𝘀𝗶𝗼𝗻𝘀, 𝘁𝗵𝗲 𝗲𝘅𝗰𝗲𝗽𝘁𝗶𝗼𝗻𝗮𝗹 𝗼𝗿𝗴𝗮𝗻𝗶𝘇𝗮𝘁𝗶𝗼𝗻, 𝘃𝗲𝗻𝘂𝗲𝘀, 𝗮𝗻𝗱 𝘀𝗼𝗰𝗶𝗮𝗹 𝗲𝘃𝗲𝗻𝘁𝘀 𝗰𝗿𝗲𝗮𝘁𝗲 𝗲𝘃𝗲𝗻 𝗺𝗼𝗿𝗲 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝗶𝗲𝘀 𝘁𝗼 𝗰𝗼𝗻𝗻𝗲𝗰𝘁. 𝗧𝗵𝗲 𝗦𝗼𝗽𝗵𝗶𝗼𝗻 𝘁𝗲𝗮𝗺’𝘀 𝗽𝗮𝘀𝘀𝗶𝗼𝗻 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝗰𝗲 𝗮𝗻𝗱 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝗳𝗼𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵𝗲𝗿𝘀 𝗶𝘀 𝗲𝘃𝗶𝗱𝗲𝗻𝘁 𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗼𝘂𝘁 𝘁𝗵𝗲 𝘀𝘆𝗺𝗽𝗼𝘀𝗶𝗮." We look forward to welcoming you to ICMS@ in Boston in 3 weeks. If you are interested in participating, you can register for the waiting list here: https://lnkd.in/ev5faFbN Our ICMS® brings together researchers, scientists, and industry professionals from around the world to exchange ideas, share the latest advancements, and explore new frontiers in ion channel modulation. The event will feature keynote speakers, poster presentations, and excellent networking opportunities. We look forward to spending two days together filled with inspiring talks and discussions. #ICMS #Qube384 #QPatch #QPatchCompact #AutomatedPatchClamp #IonChannels #DrugDiscovery #Electrophysiology #Sophion

I am excited to announce that my first chapter, titled "Implications of Systems Biology in Understanding the Pathophysiology of Neurological Diseases," has been published in the book "Systems Biology and In-Depth Applications for Unlocking Diseases," available via ScienceDirect! 📚✨ This chapter delves into how systems biology approaches can unravel the complexities of neurological diseases by offering insights into their pathophysiology. It has been an incredible journey of exploring molecular networks and understanding disease mechanisms through an interdisciplinary lens. This milestone wouldn't have been possible without the guidance and mentorship of Dr. Prachi Srivastava and Dr. Prekshe S Garg. My heartfelt thanks also go to my co-contributors, Wayez Naqvi and Ananya Singh, for their collaboration. 📅 Published: 8th November 2024 📖 Read more here: https://lnkd.in/d9DgpYBA I am thrilled to contribute to advancing research in neuroscience and systems biology, and I look forward to connecting with professionals in this field. Here's to more discoveries and collaborations ahead! 🚀 #SystemsBiology #NeurologicalDiseases #Research #Publication #Biotechnology

My Master's thesis was the first official publication I did a year ago. Continuing my work to expand my research in computational neuroscience since then with my advisor to continue with project and dip my toes in a new project. Goal will always be to create something that contributes to scientific community for improvement on how we treat learn and understand certain diseases and overcome practical drawbacks using theoretical approach. Sharing this with everyone to have a glance at: https://lnkd.in/edXf2dJm

Precision Neuroscience / Precision BioMEMS will be part of the "BCI: State of the Art, Art of the Future" panel discussion this week at the IEEE Engineering Medicine and Biology Society 2024 conference, the world’s largest international biomedical engineering conference, currently underway in Orlando. Stop by the panel session on July 18th, for what promises to be a lively and informative discussion on brain-computer interfaces and their implications for the future of healthcare. #EMBC2024

As a university professor, nothing is more satisfying than witnessing the professional growth of your students, especially when you receive such positive feedbacks, feeling that you have contributed to their success. I had the privilege of working at Amirkabir University of Technology (AUT) as an Assistant Professor for five years. That gave me the opportunity to establish and lead an independent research lab and work with amazing students, full of talent and motivation. Conducting research in a place with limited budget and equipment availability was challenging, but we did our best to remain productive and maintain high standards through hard work and sacrifice from all lab members. Last year, I decided to leave AUT and embark a new adventure at the University of Toronto. It was not an easy decision to leave the research group that I created and expanded, especially after overcoming numerous challenges, but at the same time I was (and still am) full of excitement about this new endeavor. It's almost a year since I left AUT, but the outcomes from our research during those five years are just emerging. This article just published in Microcirculation from Marzieh Bagheri's project is one, another one was published recently in Tissue Engineering Part A (link below), and more are in preparation or currently under review. I expect 2024 and 2025 to be significant in concluding those five years of work. In my current role here at the University of Toronto, I am leading a research line aimed at developing #clinically #translatable #biodegradable #embolic #agents for applications such as #osteoarthritis and #cancer #treatment, for which I'm grateful to Prof. Naomi Matsuura and Prof. Sebastian Mafeld for their trust and continuous support. We have made a great progress on this project and anticipate interesting publications in the coming months. And hopefully I could share more exciting news soon, as we are quickly expanding our research in several relevant directions. Our recent publication at Tissue Engineering Part A: https://lnkd.in/gbfuDQeM

The Dawn of Spatial Medicine Eric Topol, MD For the first time spatial omics leads to a lifesaving treatment What’s spatial medicine? We’re not talking about space medicine or going to Mars, or a form of rehab. This is about a landmark paper from the Max Planck Institute of Biochemistry, leading an international collaboration across many countries (authors and work from Germany, Japan, Denmark, China, Australia, France, Switzerland, and USA), that moved the field from spatial biology as a research tool to medicine as a therapy. I’ve coined this term to reflect the importance of this advance. https://lnkd.in/duwzwTtc Image: An overview spatial map image made by Georg Walmann at Max Planck Institute of Biochemistry. The “shoreline” is the epidermis and distinct cellular types within the dermis inner layer are tagged, involved with the life-threatening condition of toxic epidermal necrolysis. #PrecisionMedicine #Innovation #Multiomics #ArtificialIntelligence #Science #Research #Oncology #Disease #Pathology