NLRP9

NLRP9
Identifikatori
Aliasi	NLRP9
Vanjski ID-jevi	OMIM: 609663 MGI: 2675377 HomoloGene: 18530 GeneCards: NLRP9
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	55,738,402 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	19,807,231 bp
Ontologija gena
Molekularna funkcija	• ATP binding; • nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • Inflamasom;
Biološki proces	• positive regulation of interleukin-18 production; • defense response to virus; • Piroptoza; • immune system process; • inflammatory response; • Urođeni imunski sistem;
	Izvori:Amigo / QuickGO
Ortolozi
	338321
	243874
	ENSG00000185792
	ENSMUSG00000060508
	Q7RTR0
	Q66X22
	NM_176820
	NM_194058
	NP_789790
	NP_918947
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NLRP9, skraćelica za porodicu nukleotidnovezujućih oligomerizacijskih receptora sa proteinom 9, je unutarćelijski protein koji se javlja u jajnicima, sjemenicima, oocitima i preimplantacijskim embrionima sisara sisara koji je vjerovatno uključen u reprodukcijskke procese. To jest protein koji je kod ljudi kodiran genom sa q kraka hromosoma 19.^[5]^[6]^[7] Također je poznat kao NALP9, NOD6, PAN12 i CLR19.1, i jedan je od 14 pirinskih domena koji sadrže članove porodice NOD-sličnih citoplazmatskih receptora.

Aminokiselinska sekvenca

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185792 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060508 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dalbiès-Tran R, Papillier P, Pennetier S, Uzbekova S, Monget P (august 2005). "Bovine mater-like NALP9 is an oocyte marker gene". Mol. Reprod. Dev. 71 (4): 414–21. doi:10.1002/mrd.20298. PMID 15892040. S2CID 33157680.
^ Ponsuksili S, Brunner RM, Goldammer T, et al. (mart 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045.
^ Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372.

Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.