HDAC4

HDAC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
Dynodwyr
Cyfenwau	HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID
Dynodwyr allanol	OMIM: 605314 HomoloGene: 55946 GeneCards: HDAC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • NAD-dependent histone deacetylase activity (H3-K14 specific) • sequence-specific DNA binding • DNA binding • GO:0001106 transcription corepressor activity • histone deacetylase activity • zinc ion binding • transcription factor binding • histone deacetylase binding • potassium ion binding • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • hydrolase activity • protein deacetylase activity • identical protein binding • promoter-specific chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • SUMO transferase activity Cydrannau o'r gell • cytoplasm • histone deacetylase complex • neuromuscular junction • transcription repressor complex • sarcomere • Z discdkac • A band • actomyosin • cnewyllyn cell • cytosol • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of reactive oxygen species biosynthetic process • histone H3 deacetylation • skeletal system development • chromatin remodeling • peptidyl-lysine deacetylation • regulation of cardiac muscle contraction by calcium ion signaling • negative regulation of glycolytic process • response to interleukin-1 • GO:0009373 regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • cellular response to tumor necrosis factor • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of protein sumoylation • negative regulation of DNA-binding transcription factor activity • negative regulation of osteoblast differentiation • transcription, DNA-templated • nervous system development • regulation of striated muscle cell differentiation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of smooth muscle cell migration • B cell activation • histone H4 deacetylation • cellular response to mechanical stimulus • positive regulation of neuron apoptotic process • cardiac muscle hypertrophy in response to stress • positive regulation of cell population proliferation • negative regulation of myotube differentiation • response to denervation involved in regulation of muscle adaptation • regulation of skeletal muscle fiber development • osteoblast development • B cell differentiation • cellular response to parathyroid hormone stimulus • inflammatory response • positive regulation of lamellipodium assembly • regulation of protein binding • GO:0045996 negative regulation of transcription, DNA-templated • histone deacetylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • positive regulation of smooth muscle cell proliferation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • negative regulation of pri-miRNA transcription by RNA polymerase II • protein deacetylation • protein sumoylation • positive regulation of male mating behavior Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9759	n/a
Ensembl	ENSG00000068024	n/a
UniProt	P56524	n/a
RefSeq (mRNA)	NM_006037 NM_001378414 NM_001378415 NM_001378416 NM_001378417	n/a
RefSeq (protein)	NP_006028 NP_001365343 NP_001365344 NP_001365345 NP_001365346	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HDAC4 yw HDAC4 a elwir hefyd yn Histone deacetylase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q37.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HDAC4.

• "Peripheral Blood Mononuclear Cell Gene Expression Remains Broadly Altered Years after Successful Interferon-Based Hepatitis C Virus Treatment. ". J Immunol Res. 2015. PMID 26568966.
• "Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis. ". BMC Musculoskelet Disord. 2014. PMID 25515592.
• "Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma. ". Aging (Albany NY). 2016. PMID 27295551.
• "Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4. ". Biochem Biophys Res Commun. 2016. PMID 27150631.
• "Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation.". Biochim Biophys Acta. 2016. PMID 27106144.