JAK1

JAK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI
Dynodwyr
Cyfenwau	JAK1, JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDE
Dynodwyr allanol	OMIM: 147795 HomoloGene: 1678 GeneCards: JAK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • CCR5 chemokine receptor binding • growth hormone receptor binding • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • protein phosphatase binding • signaling receptor binding • ATP binding • ubiquitin protein ligase binding • non-membrane spanning protein tyrosine kinase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • Cytosgerbwd • endomembrane system • cnewyllyn cell • endosome Prosesau biolegol • cell differentiation • GO:0007243 intracellular signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • interferon-gamma-mediated signaling pathway • GO:1904576 response to antibiotic • MAPK cascade • positive regulation of sprouting angiogenesis • protein phosphorylation • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • regulation of cell population proliferation • type I interferon signaling pathway • interleukin-2-mediated signaling pathway • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • cell migration • innate immune response • interleukin-12-mediated signaling pathway • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • interleukin-9-mediated signaling pathway • regulation of molecular function • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • interleukin-21-mediated signaling pathway • interleukin-6-mediated signaling pathway • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3716	n/a
Ensembl	ENSG00000162434	n/a
UniProt	P23458	n/a
RefSeq (mRNA)	NM_002227 NM_001320923 NM_001321852 NM_001321853 NM_001321854 NM_001321855 NM_001321856 NM_001321857	n/a
RefSeq (protein)	NP_001307852 NP_001308781 NP_001308782 NP_001308783 NP_001308784 NP_001308785 NP_001308786 NP_002218	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn JAK1 yw JAK1 a elwir hefyd yn Janus kinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p31.3.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn JAK1.

• JTK3
• JAK1A
• JAK1B

• "Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion. ". PLoS One. 2017. PMID 29121062.
• "Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1. ". Genome Med. 2017. PMID 28539123.
• "Nuclear Import of JAK1 Is Mediated by a Classical NLS and Is Required for Survival of Diffuse Large B-cell Lymphoma. ". Mol Cancer Res. 2017. PMID 28031410.
• "Association between JAK1 gene polymorphisms and susceptibility to allergic rhinitis. ". Asian Pac J Allergy Immunol. 2016. PMID 27007833.
• "Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.". Oncotarget. 2016. PMID 26701727.