KCND3

KCND3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1S1G, 2NZ0
Dynodwyr
Cyfenwau	KCND3, KCND3L, KCND3S, KSHIVB, KV4.3, SCA19, SCA22, BRGDA9, potassium voltage-gated channel subfamily D member 3
Dynodwyr allanol	OMIM: 605411 HomoloGene: 21036 GeneCards: KCND3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • potassium channel activity • transmembrane transporter binding • metal ion binding • voltage-gated ion channel activity • ion channel activity • GO:0001948, GO:0016582 protein binding • voltage-gated potassium channel activity • A-type (transient outward) potassium channel activity • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Cydrannau o'r gell • integral component of membrane • cell projection • bilen • voltage-gated potassium channel complex • Cellbilen • dendrite • sarcolemma • GABA-ergic synapse • integral component of postsynaptic specialization membrane • soma Prosesau biolegol • regulation of ion transmembrane transport • cludo ïon • potassium ion transport • membrane repolarization • transmembrane transport • potassium ion transmembrane transport • protein homooligomerization • membrane repolarization during cardiac muscle cell action potential • regulation of heart rate by cardiac conduction • potassium ion export across plasma membrane • membrane repolarization during ventricular cardiac muscle cell action potential • ventricular cardiac muscle cell membrane repolarization • cardiac conduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3752	n/a
Ensembl	ENSG00000171385	n/a
UniProt	Q9UK17	n/a
RefSeq (mRNA)	NM_004980 NM_172198 NM_001378969 NM_001378970	n/a
RefSeq (protein)	NP_004971 NP_751948 NP_001365898 NP_001365899	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCND3 yw KCND3 a elwir hefyd yn Potassium voltage-gated channel subfamily D member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCND3.

• "Modulation of the transient outward current (Ito) in rat cardiac myocytes and human Kv4.3 channels by mefloquine. ". Toxicol Appl Pharmacol. 2015. PMID 26216464.
• "Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner. ". Cell Mol Life Sci. 2015. PMID 25854634.
• "The potential role of Kv4.3 K+ channel in heart hypertrophy. ". Channels (Austin). 2014. PMID 24762397.
• "The L450F [Corrected] mutation in KCND3 brings spinocerebellar ataxia and Brugada syndrome closer together. ". Neurogenetics. 2013. PMID 23963749.
• "A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation.". Cardiovasc Res. 2013. PMID 23400760.