Anadenanthera peregrina

This plant is almost identical to that of a related tree, Anadenanthera colubrina,^[5] commonly known as cebíl or vilca.^[6] The beans of A. colubrina have a similar chemical makeup as Anadenanthera peregrina, with their primary constituent being bufotenin.^[6]

• Anadenanthera peregrina var. falcata
• Anadenanthera peregrina var. peregrina

The wood from A. peregrina produces very hard timber that is used for making furniture.^[7] It has a Janka rating of 3700 lb.^{[8][failed verification]} and a density of around 0.86 g/cm³.^[9] Tannins have also been derived from this plant.^[4]

The beans (sometimes called seeds) and falling leaves are hallucinogenic and are toxic to cattle.[1]

Chemical compounds contained in A. peregrina include:

• 2,9-dimethyltryptoline – plant^[10]
• 2-methyltryptoline – plant^[10]
• 5-MeO-DMT – bark,^[10] bean
• 5-Methoxy-N-methyltryptamine – bark^[10]
• Bufotenin – plant^[10] beans^[11]
• Bufotenin-oxide – fruit,^[10] beans^[11]
• Catechol – plant^[10]
• Leucoanthocyanin – plant^[10]
• Leucopelargonidol – plant^[10]
• DMT – fruit,^[10] beans, pods,^[11] bark^[12]
• DMT-oxide – fruit^[10][13]
• N-Methyltryptamine – bark^[10]
• Orientin – leaf^[10]
• Saponarentin – leaf^[10]
• Viterine – leaf^[10]

The bark contains a high percentage of tannins, 587 mg CE/g extract.^[14]

Archaeological evidence shows Anadenanthera beans have been used as hallucinogens for thousands of years. The oldest clear evidence of use comes from pipes made of puma bone (Puma concolor) found with Anadenanthera beans presumably of the sister species A. colubrina, at Inca Cueva, a site in the Humahuaca gorge at the edge of the Puna of Jujuy Province, Argentina. The pipes were found to contain the hallucinogen DMT, one of the compounds found in Anadenanthera beans. Radiocarbon testing of the material gave a date of 2130 BC, suggesting that Anadenanthera use as a hallucinogen is over 4,000 years old.^[15] Snuff trays and tubes similar to those commonly used for yopo were found in the central Peruvian coast dating back to 1200 BC, suggesting that insufflation of Anadenanthera beans is a more recent method of use.^[16] Archaeological evidence of insufflation use within the period 500-1000 AD, in northern Chile, has been reported.^[17]

Some indigenous peoples of the Orinoco basin in Colombia, Venezuela and possibly in the southern part of the Brazilian Amazon make use of yopo snuff for spiritual healing. Yopo snuff was also widely used in ceremonial contexts in the Caribbean area, including Puerto Rico and La Española, up to the Spanish Conquest.

Yopo snuff is usually blown into the user's nostrils by another person through bamboo tubes or sometimes snuffed by the user using bird bone tubes. Blowing is more effective as this method allows more powder to enter the nose and is said to be less irritating. In some areas the unprocessed ground beans are snuffed or smoked producing a much weaker effect with stronger physical symptoms. Some tribes use yopo along with Banisteriopsis caapi to increase and prolong the visionary effects, creating an experience similar to that of ayahuasca.

The first report of the effects of hallucinogenic snuff prepared from the beans of Anadenanthera peregrina dates back to 1496 when it was observed by Friar Ramon Pane, who was commissioned by Christopher Columbus, among the Taino Indians of Hispaniola. Pane's report was first published in 1511 in Martyr's descriptions of the New World. The description of its effects reads in part: "This kohobba powder," described as "an intoxicating herb, is so strong that those who take it lose consciousness; when the stupefying action begins to wane, the arms and legs become loose and the head droops." It is administered with a cane about one foot long of which they introduce one end "in the nose and the other in the powder and ...draw it into themselves through the nose". It worked quickly: "almost immediately they believe they see the room turn upside-down and men walking with their heads downwards". The administering witch-doctor took the drug along with his patients, intoxicating "them so that they do not know what they do and ... speak of many things incoherently", believing that they are in communication with spirits.^[18]

The beans have been found to contain up to 7.4% bufotenin.^[19] At up to 7.4% (74 mg per gram) bufotenin, an effective 40 mg dose of insufflated bufotenin^[19] requires little more than 0.5 grams of beans.

The intraperitoneal LD₅₀ of bufotenin is between 200 and 300 mg/kg (in rodents) with death occurring by respiratory arrest.^[20] Human intravenous tests using bufotenin suggest the LD₅₀ may be much lower in humans with subjects showing signs of peripheral toxicity (purple face, tachycardia, difficulty breathing, etc.) at doses as little as 8 mg in some subjects.^[21] Free base bufotenin when insufflated, taken sublingually, orally, or intrarectally, elicits strong hallucinogenic effects with far less side effects.^[19]

The beans have been found to contain up to only 0.04% 5-MeO-DMT and 0.16% DMT.^[19] The leaves and bark also contain small amounts of DMT, 5-MeO-DMT and related compounds.^[22][23][24]

At up to 0.04% (0.4 mg per gram) 5-MeO-DMT, an effective light 5 mg dose of insufflated 5-MeO-DMT would require over 12 grams of beans. It would be extremely difficult to insufflate such a quantity, as tolerance would likely develop before the 12-gram nasal intake could be completed. Individual sensitivity to 5-MeO-DMT varies. It has been documented that the threshold dose in some individuals is as much as 10 mg insufflated^[25] requiring over 24 grams of beans for an effective dose of 5-MeO-DMT.

At up to 0.16% (1.6 mg per gram) DMT, an effective 40 mg dose of insufflated DMT would require 25 grams or more. Because of its volume, it's likely to be impossible to insufflate the 25 grams of beans required to reach the active dose of DMT present in the beans. An extract of 25 grams of beans could contain up to 1,850 mg of bufotenin, a potentially dangerous dose. With insufflated freebase bufotenin, the maximum published safe dose used has been 100 mg.^[19]

Unlike bufotenin, both DMT and 5-MeO-DMT are relatively unstable and begin to degrade rather quickly. Schultes and colleges (1977) examined a 120-year-old bean collection and found 0.6% bufotenin with no DMT or 5-MeO-DMT present at all. They also examined a batch of beans that contained all three compounds when fresh, but found only bufotenin in the beans after only two years of storage.^[20]

When taken orally by some tribes in South America, small amounts are often combined with alcoholic chichas (maize beer).^[20]: 29 Moderate doses are unpleasant, producing nausea and vomiting. The beans were a main ingredient in bilca tauri, an oral purge medicine used to induce ritual vomiting once a month.^[20] Large amounts are not usually consumed orally as many tribes believe oral use is dangerous.

Some South American tribes have been documented to use various bean preparations along with Banisteriopsis caapi, an herb containing monoamine oxidase inhibitors (MAOIs).^[20] Typically Banisteriopsis caapi is chewed in the mouth while the Anadenanthera beans are snuffed or smoked.^[20] Occasionally Banisteriopsis caapi is found mixed in with the snuff.^[20]

• Anadenanthera colubrina
• Cohoba
• List of plants of Caatinga vegetation of Brazil
• Nu-nu, a psychotropic snuff used by Matsés people
• Psychedelic plants

• Richard Evans Schultes (1992). Plants of the Gods. Inner Traditions/Bear. ISBN 0-89281-979-0.

• Erowid Anadenanthera Vault