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Scott D. Emr

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Scott D. Emr
Born
Scott David Emr[2]

(1954-02-08)February 8, 1954
Jersey City, New Jersey, United States[1]
NationalityAmerican
Alma materHarvard University
University of Rhode Island[3]
Known forResearch in membrane vesicle trafficking
SpouseMichelle Emr[4]
Children2[4]
AwardsShaw Prize in Life science and Medicine
Scientific career
FieldsCell biology
InstitutionsCornell University
University of California, San Diego
Howard Hughes Medical Institute
California Institute of Technology
University of California, Berkeley[1]
ThesisProtein localization in Escherichia coli (1981)
Doctoral advisorThomas Silhavy
Jonathan Beckwith

Scott D. Emr (born February 8, 1954) is an American cell biologist and the founding and current Director of the Weill Institute for Cell and Molecular Biology at Cornell University, where he is also a Frank H.T. Rhodes Class of 1956 Professor at the Department of Molecular Biology and Genetics.[5]

Early life and education

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Emr was born in Jersey City[1] and grew up in Fort Lee, New Jersey. His father was a manager of a manufacturing company. He has a sister and two brothers.[4]

The 1960s documentary The Undersea World of Jacques Cousteau prompted him to pick a university with a strong oceanography program, starting in 1972 at the University of Rhode Island as a biology major. He became interested in genetics during his undergraduate years.[4] He started his PhD in 1976 at the Department of Microbiology and Molecular Genetics at Harvard University, working under Thomas Silhavy and Jonathan Beckwith and graduating in 1981.[3][4]

Career

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Emr began his career at the University of California, Berkeley as a Miller Institute Fellow[6] and a postdoctoral researcher at Randy Schekman's group.[4] He moved to the California Institute of Technology in 1983, becoming an assistant, and later associate professor, at the Division of Biology.[3]

George Emil Palade recruited Emr to the University of California, San Diego in 1991,[4] where he stayed as a Distinguished Professor at the Department of Cellular and Molecular Medicine and, at the same time, an investigator at the Howard Hughes Medical Institute.[7] He left for Cornell University in 2007 when he was appointed as the founding director of the Institute of Cell and Molecular Biology (later renamed to Weill Institute for Cell and Molecular Biology after a donation from Joan and Sanford I. Weill)[8] and a Frank H.T. Rhodes Class of 1956 Professor at the Department of Molecular Biology and Genetics.[3][9]

Academically, Emr serves on the editorial boards of several scientific journals, including (as of 2021) mBio,[10] Journal of Cell Biology,[11] Trends in Cell Biology,[12] and Current Opinion in Cell Biology.[13]

Research

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Emr's research focuses on the regulation of membrane vesicle trafficking pathways. His lab's study of the ESCRT (endosomal sorting complexes required for transport) complexes earned him a Shaw Prize in Life Science and Medicine.[14] ESCRTs are required for the degradation of membrane protein at the lysosome, a late step in cytokinesis, and the budding and release of human immunodeficiency virus (HIV).[3][5][15][16]

His other research interests include lipid signaling (especially a group of lipids known as phosphatidylinositol phosphates),[17] protein transport in cells by vesicles[18] and the role of arrestin and ubiquitylation in the degradation of membrane proteins.[3][5][19]

Honors and awards

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Personal life

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Emr met his wife Michelle in his junior year at university. She was also in her third year, majoring in music and early education. They married three years later when Emr was pursuing his PhD. As of 2021, their daughter Bryanna is a pediatric surgeon in Pittsburgh, and their son Kevin is an anesthesiologist in Albany, New York.[4]

References

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  1. ^ a b c d "Scott D Emr". The Shaw Prize Foundation. June 1, 2021. Archived from the original on November 6, 2021. Retrieved November 6, 2021.
  2. ^ Emr, Scott David (1981). Protein localization in Escherichia coli (PhD). Harvard University. Retrieved November 6, 2021.
  3. ^ a b c d e f "BIOGRAPHICAL SKETCH" (PDF). Cornell University. 2017. Archived from the original (PDF) on November 6, 2021. Retrieved November 6, 2021.
  4. ^ a b c d e f g h "Autobiography of Scott D Emr". The Shaw Prize Foundation. Archived from the original on November 6, 2021. Retrieved November 6, 2021.
  5. ^ a b c "The Emr Lab". Cornell University. Archived from the original on November 8, 2021. Retrieved November 8, 2021.
  6. ^ "All Miller Fellows: By Name". University of California, Berkeley. Archived from the original on November 12, 2021. Retrieved November 12, 2021.
  7. ^ "Scott D. Emr, PhD". Howard Hughes Medical Institute. Archived from the original on November 16, 2021. Retrieved November 16, 2021.
  8. ^ Ramanujan, Krishna (June 13, 2007). "Institute for Cell and Molecular Biology benefits from $25 million gift from the Weills". Cornell Chronicle. Archived from the original on November 15, 2021. Retrieved November 15, 2021.
  9. ^ Ramanujan, Krishna (May 24, 2006). "A major hire to advance and extend life sciences at Cornell". Cornell Chronicle. Archived from the original on November 16, 2021. Retrieved November 16, 2021.
  10. ^ "mBio Board of Editors". mBio. Archived from the original on November 19, 2021. Retrieved November 19, 2021.
  11. ^ "Editorial Board". Journal of Cell Biology. Archived from the original on August 14, 2021. Retrieved November 23, 2021.
  12. ^ "Advisory board". Trends in Cell Biology. Archived from the original on November 23, 2021. Retrieved November 23, 2021.
  13. ^ "Editorial Board". Current Opinion in Cell Biology. Archived from the original on November 23, 2021. Retrieved November 23, 2021.
  14. ^ "Press Release" (Press release). The Shaw Prize Foundation. June 1, 2021. Archived from the original on November 24, 2021. Retrieved November 24, 2021.
  15. ^ Katzmann, David J.; Babst, Markus; Emr, Scott D. (2001). "Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I". Cell. 106 (2): 145–155. doi:10.1016/S0092-8674(01)00434-2. PMID 11511343.
  16. ^ Banjade, Sudeep; Tsang, Shaogeng; Shah, Yousuf H; Emr, Scott D (2019). "Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly". eLife. 8: e46207. doi:10.7554/eLife.46207. PMC 6663469. PMID 31246173.
  17. ^ Burd, Christopher G; Emr, Scott D (1998). "Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains". Molecular Cell. 2 (1): 157–162. doi:10.1016/S1097-2765(00)80125-2. PMID 9702203.
  18. ^ Suzuki, Sho W.; Emr, Scott D. (2018). "Membrane protein recycling from the vacuole/lysosome membrane". Journal of Cell Biology. 217 (5): 1623–1632. doi:10.1083/jcb.201709162. PMC 5940307. PMID 29511122. Archived from the original on November 29, 2021. Retrieved November 29, 2021.
  19. ^ Lin, Charles H.; MacGurn, Jason A.; Chu, Tony; Stefan, Christopher J.; Emr, Scott D. (2008). "Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface". Cell. 135 (4): 714–725. doi:10.1016/j.cell.2008.09.025. PMID 18976803.
  20. ^ a b Spiro, Mary (September 22, 2017). "Cornell's Scott D. Emr to deliver 2017 Porter Lecture" (Press release). American Society for Cell Biology. Archived from the original on June 8, 2021. Retrieved June 8, 2021.
  21. ^ "Elected Fellows". American Association for the Advancement of Science. Archived from the original on November 19, 2021. Retrieved November 19, 2021.
  22. ^ "Scott D. Emr". American Academy of Arts and Sciences. Archived from the original on November 22, 2021. Retrieved November 22, 2021.
  23. ^ "Scott D. Emr". National Academy of Sciences. Archived from the original on June 2, 2019. Retrieved November 19, 2021.
  24. ^ "72 new members chosen by academy". EurekAlert!. May 1, 2007. Archived from the original on November 19, 2021. Retrieved November 19, 2021.
  25. ^ "Avanti Award in Lipids". American Society for Biochemistry and Molecular Biology. Archived from the original on November 21, 2021. Retrieved November 21, 2021.
  26. ^ "Scott D. Emr". European Molecular Biology Organization. Archived from the original on November 21, 2021. Retrieved November 21, 2021.
  27. ^ Ramanujan, Krishna (October 16, 2008). "Emr elected associate member of elite European Molecular Biology Organization". Cornell Chronicle. Archived from the original on November 22, 2021. Retrieved November 22, 2021.
  28. ^ "Van Deenen Medal". Institute of Biomembranes, Utrecht University. Archived from the original on November 9, 2021. Retrieved November 21, 2021.
  29. ^ "Keith R. Porter Lecture". American Society for Cell Biology. Archived from the original on November 22, 2021. Retrieved November 22, 2021.
  30. ^ "Scott Emr". American Society for Cell Biology. Archived from the original on November 22, 2021. Retrieved November 22, 2021.
  31. ^ Louisa Gross Horwitz Prize 2024
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