The Central region of New York is a crossroads, dominated by the state's fifth-largest city, Syracuse, and the Mohawk River that flows eastward through this region. It borrows aspects from all of the surrounding regions to create a microcosm of New York as a whole: hills and rivers, cities and farms, hard work and recreation. Central New York is sometimes called the "Gateway to the Adirondacks" and is a natural starting point for fall foliage expeditions. It is also rich in history: The battle of Oriskany and the siege of Fort Stanwix figured prominently in the American revolutionary war.

42°54′36″N 75°42′0″W

Map of Central New York

• 42.293-75.4791 Bainbridge
• 42.93-75.8532 Cazenovia
• 43.150556-76.1941673 Clay
• 43.049-75.3794 Clinton — home of Hamilton College
• 42.697-74.9275 Cooperstown — known as the home of the National Baseball Hall of Fame and Museum; also home to the Farmers' Museum, the Fenimore Art Museum, The New York State Historical Association (NYSHA) library and the Ommegang Brewery, and has a pretty historic district
• 42.601-76.186 Cortland
• 43.026-74.997 Herkimer (and Ilion and Mohawk)
• 43.043-74.858 Little Falls
• 42.531-75.5239 Norwich
• 43.085-75.65333310 Oneida
• 42.452-75.06311 Oneonta — a town with a lovely historic district and two colleges
• 43.45-76.512 Oswego — a small city with important wartime history and legacy from the Revolutionary War to World War II, also home to a SUNY college
• 43.565-76.12513 Pulaski
• 43.219-75.46314 Rome
• 43.048-76.14715 Syracuse — the major regional population, economic and cultural hub, home to Syracuse University
• 43.1-75.23316 Utica — a city with some nice buildings from the industrial era and good cultural institutions for a community of its size