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Update readme to point to newer case-studies
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kishwarshafin authored and copybara-github committed Dec 3, 2024
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Expand Up @@ -11,27 +11,33 @@ a standard VCF or gVCF file.

DeepVariant supports germline variant-calling in diploid organisms.

**DeepVariant case-studies for germline variant calling:**

* NGS (Illumina or Element) data for either a
[whole genome](docs/deepvariant-case-study.md) or
[whole exome](docs/deepvariant-exome-case-study.md).
* [RNA-seq Case Study](docs/deepvariant-rnaseq-case-study.md) for Illumina
RNA-seq.
* PacBio HiFi data, see the
[PacBio case study](docs/deepvariant-pacbio-model-case-study.md).
* [PacBio Iso-Seq/MAS-Seq Case Study](docs/deepvariant-masseq-case-study.md).
* Oxford Nanopore R10.4.1 Simplex or Duplex data, see the
[ONT R10.4.1 Simplex case study](docs/deepvariant-ont-r104-simplex-case-study.md)
and
[ONT R10.4.1 Duplex case study](docs/deepvariant-ont-r104-duplex-case-study.md).
* PacBio [Iso-Seq/MAS-Seq case study](docs/deepvariant-masseq-case-study.md).
* Oxford Nanopore R10.4.1
[Simplex case study](docs/deepvariant-ont-r104-simplex-case-study.md),
[Duplex case study](docs/deepvariant-ont-r104-duplex-case-study.md).
* Complete Genomics
[T7 case study](docs/deepvariant-complete-t7-case-study.md);
[G400 case study](docs/deepvariant-complete-g400-case-study.md).
* Pangenome-mapping-based case-study:
[vg case study](docs/deepvariant-vg-case-study.md).
* Illumina [RNA-seq Case Study](docs/deepvariant-rnaseq-case-study.md).
* Hybrid PacBio HiFi + Illumina WGS, see the
[hybrid case study](docs/deepvariant-hybrid-case-study.md).
* Oxford Nanopore R9.4.1 data by using
[PEPPER-DeepVariant](https://github.com/kishwarshafin/pepper).
* To map using a pangenome to improve accuracy, use this
[vg case study](docs/deepvariant-vg-case-study.md).
* Complete Genomics data:
[T7 case study](docs/deepvariant-complete-t7-case-study.md);
[G400 case study](docs/deepvariant-complete-g400-case-study.md)

**Pangenome-aware DeepVariant case-studies:**

* Pangenome-aware DeepVariant WGS (Illumina or Element):
[Mapped with BWA](docs/pangenome-aware-wgs-bwa-case-study.md),
[Mapped with VG](docs/pangenome-aware-wgs-vg-case-study.md).
* Pangenome-aware DeepVariant WES (Illumina or Element):
[Mapped with BWA](docs/pangenome-aware-wes-bwa-case-study.md).

We have also adapted DeepVariant for somatic calling. See the
[github.com/google/deepsomatic](DeepSomatic) repo for details.
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~$0.89 to call an exome. With preemptible pricing, the cost is $2.84 for a
30x whole genome and $0.21 for whole exome (not considering preemption).
* **Speed** - See [metrics](docs/metrics.md) for the runtime of all supported
datatypes on a 64-core CPU-only machine</sup>. Multiple options for
datatypes on a 96-core CPU-only machine</sup>. Multiple options for
acceleration exist.
* **Usage options** - DeepVariant can be run via Docker or binaries, using
both on-premise hardware or in the cloud, with support for hardware
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