3(ili 17)b-hidroksisteroid dehidrogenaza
| 3(ili 17)b-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.51 | ||||||||
| CAS broj | 9015-81-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3(ili 17)b-hidroksisteroid dehidrogenaza (EC 1.1.1.51, beta-hidroksi steroidna dehidrogenaza, 17-ketoreduktaza, 17beta-hidroksi steroidna dehidrogenaza, 3beta-hidroksisteroidna dehidrogenaza, 3beta-hidroksi steroidna dehidrogenaza) je enzim sa sistematskim imenom 3(or 17)beta-hidroksisteroid:NAD(P)+ oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- testosteron + NAD(P)+ androstendion + NAD(P)H + H+
Takođe deluje na druge 3beta- ili 17beta-hidroksisteroide, cf. EC 1.1.1.209 3(ili 17)alfa-hidroksisteroidna dehidrogenaza.
- ↑ Dahm, K. and Breuer, H. (1964). „Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte”. Hoppe-Seyler's Z. Physiol. Chem. 336: 63-68. PMID 14214322.
- ↑ Lynn, W.S. and Brown, R.H. (1958). „The conversion of progesterone to androgens by testes”. J. Biol. Chem. 232: 1015-1030. PMID 13549484.
- ↑ Marcus, P.I. and Talalay, P. (1956). „Induction and purification of α- and β-hydroxysteroid dehydrogenases”. J. Biol. Chem. 218: 661-674. PMID 13295221.
- ↑ Schultz, R.M., Groman, F.V. and Engel, L.L. (1977). „3(17)β-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms”. J. Biol. Chem. 252: 3775-3783. PMID 193845.
- ↑ Talalay, P. and Dobson, M.M. (1953). „Purification and properties of a α-hydroxysteroid dehydrogenase”. J. Biol. Chem. 205: 823-837. PMID 13129261.
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