Dopaminski receptor D₅

Dopaminski receptor D5
Identifikatori
Simboli	DRD5; DBDR; DRD1B; DRD1L2
Vanjski ID	OMIM: 126453 MGI: 94927 HomoloGene: 20216 IUPHAR: D5 GeneCards: DRD5 Gene
Ontologija gena
Molekularna funkcija	• aktivnost dopaminskog receptora, Gs spregnutog; • vezivanje G-protein alfa podjedinice; • aktivnost transfera signala; • receptorska aktivnost; • aktivnost G-protein spregnutog receptora; • aktivnost dopaminskog receptora; • vezivanje leka; • vezivanje dopamina;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom;
Biološki proces	• sinaptička transmisija, dopaminergička; • respons na amftamin; • regulacija sistemskog arterijskog krvnog pritiska vazopresinom; • norepinefrin-epinefrin vazokonstrikcija; • negativna regulacija aktivnosti proteinske kinaze; • homeostaza ćelijskih jona kalcijuma; • aktivacija adenilat ciklaze aktivnošću G-protein signalnog puta; • aktivacija adenilat ciklazne aktivnosti; • aktivacija adenilat ciklazne aktivnosti signalnim putem dopaminskog receptora; • sinaptička transmisija; • ponašanje parenja;
Pregled RNK izražavanja
	podaci
Ortolozi

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D(1B) dopaminski receptor je protein koji je kod ljudi kodiran DRD5 genom.^[1]^[2]^[3]

Dopaminski D₅ podtip je G protein spregnuti receptor koji stimuliše adenilil ciklazu.^[4] Ovaj receptor je izražen u neuronima limbičkog regiona mozga. On ima 10-puta veći afinitet za dopamin nego D₁ podtip. Pseudogeni srodni sa ovim genom se nalaze na hromozomu 1 i hromozomu 2.^[2]

Ligandi

D₁ i D₅ receptori su u znatnoj meri strukturno homologni i mali broj selektivnih liganda je dostupan. Postoje brojni ligandi koji su selektivni za D_1/5 u odnosu na druge dopaminske receptore. Nedavni razvoj selektivnog D₅ antagonista je omogućio ispitivanje D₁-posredovanog odgovora u odsustvu D₅ komponente. Selektivni D₅ agonisti trenutno nisu dostupni.

Agonist

Dihidreksidin

Antagonist

4-Hloro-7-metil-5,6,7,8,9,14-heksahidrodibenz[d,g]azecin-3-ol: antagonist, umerena selektivnost vezivanja u odnosu na D₁^[5]

Hemijska struktura D₅ selektivnog liganda 4-hloro-7-metil-5,6,7,8,9,14-heksahidrodibenz[*d,g*]azecin-3-ol.^[5]

Interakcije

Za dopaminski receptor D5 je pokazano da interaguje sa GABRG2.^[6]

Reference

↑ Polymeropoulos MH, Xiao H, Merril CR (Mar 1992). „The human D5 dopamine receptor (DRD5) maps on chromosome 4”. Genomics 11 (3): 777–778. DOI:10.1016/0888-7543(91)90091-R. PMID 1774076.
↑ ^2,0 ^2,1 „Entrez Gene: DRD5 dopamine receptor D5”.
↑ Polymeropoulos MH, Xiao H, Merril CR (1991). „The human D₅ dopamine receptor (DRD5) maps on chromosome 4”. Genomics 11 (3): 777–778. DOI:10.1016/0888-7543(91)90091-R. PMID 1774076.
↑ Sidhu A (1998). „Coupling of D₁ and D₅ dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling”. Mol. Neurobiol. 16 (2): 125–134. DOI:10.1007/BF02740640. PMID 9588624.
↑ ^5,0 ^5,1 Mohr P, Decker M, Enzensperger C, Lehmann J (2006). „Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D₅-selective dopamine-receptor antagonist”. J. Med. Chem. 49 (6): 2110–2116. DOI:10.1021/jm051237e. PMID 16539400.
↑ Liu, F; Wan Q, Pristupa Z B, Yu X M, Wang Y T, Niznik H B (January 2000). „Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors”. Nature (England) 403 (6767): 274–280. DOI:10.1038/35002014. ISSN 0028-0836. PMID 10659839.

Literatura

Missale C, Nash SR, Robinson SW i dr.. (1998). „Dopamine receptors: from structure to function”. Physiol. Rev. 78 (1): 189–225. PMID 9457173.
Grandy DK, Allen LJ, Zhang Y i dr.. (1992). „Chromosomal localization of three human D5 dopamine receptor genes”. Genomics 13 (4): 968–973. DOI:10.1016/0888-7543(92)90009-H. PMID 1387108.
Eubanks JH, Altherr M, Wagner-McPherson C i dr.. (1992). „Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus”. Genomics 12 (3): 510–516. DOI:10.1016/0888-7543(92)90442-U. PMID 1532789.
Sunahara RK, Guan HC, O'Dowd BF i dr.. (1991). „Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1”. Nature 350 (6319): 614–619. DOI:10.1038/350614a0. PMID 1826762.
Tiberi M, Jarvie KR, Silvia C i dr.. (1991). „Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor”. Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491–7495. DOI:10.1073/pnas.88.17.7491. PMC 52326. PMID 1831904.
Grandy DK, Zhang YA, Bouvier C i dr.. (1991). „Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes”. Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9175–9179. DOI:10.1073/pnas.88.20.9175. PMC 52675. PMID 1833775.
Weinshank RL, Adham N, Macchi M i dr.. (1991). „Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene”. J. Biol. Chem. 266 (33): 22427–35. PMID 1834671.
Sobell JL, Lind TJ, Sigurdson DC i dr.. (1995). „The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease”. Hum. Mol. Genet. 4 (4): 507–514. DOI:10.1093/hmg/4.4.507. PMID 7633397.
Beischlag TV, Marchese A, Meador-Woodruff JH i dr.. (1995). „The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region”. Biochemistry 34 (17): 5960–5970. DOI:10.1021/bi00017a025. PMID 7727453.
Sherrington R, Mankoo B, Attwood J i dr.. (1994). „Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1”. Genomics 18 (2): 423–425. DOI:10.1006/geno.1993.1489. PMID 8288248.
Sidhu A, Kimura K, Uh M i dr.. (1998). „Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz”. J. Neurochem. 70 (6): 2459–2467. DOI:10.1046/j.1471-4159.1998.70062459.x. PMID 9603210.
Cargill M, Altshuler D, Ireland J i dr.. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes”. Nat. Genet. 22 (3): 231–238. DOI:10.1038/10290. PMID 10391209.
Liu F, Wan Q, Pristupa ZB i dr.. (2000). „Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors”. Nature 403 (6767): 274–280. DOI:10.1038/35002014. PMID 10659839.
Misbahuddin A, Placzek MR, Chaudhuri KR i dr.. (2004). „A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm”. Neurology 58 (1): 124–6. PMID 11781417.
Kabbani N, Negyessy L, Lin R i dr.. (2002). „Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor”. J. Neurosci. 22 (19): 8476–86. PMID 12351722.
Strausberg RL, Feingold EA, Grouse LH i dr.. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hemby SE, Trojanowski JQ, Ginsberg SD (2003). „Neuron-specific age-related decreases in dopamine receptor subtype mRNAs”. J. Comp. Neurol. 456 (2): 176–183. DOI:10.1002/cne.10525. PMID 12509874.
Zheng S, Yu P, Zeng C i dr.. (2003). „Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron”. Hypertension 41 (3): 604–610. DOI:10.1161/01.HYP.0000057422.75590.D7. PMID 12623966.

Povezano

Dopaminski receptor

Spoljašnje veze

„Dopamine Receptors: D₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-12-31.
MeSH DRD5+protein,+human

[pmid1774076-1] Polymeropoulos MH, Xiao H, Merril CR (Mar 1992). „The human D5 dopamine receptor (DRD5) maps on chromosome 4”. Genomics 11 (3): 777–778. DOI:10.1016/0888-7543(91)90091-R. PMID 1774076.

[entrez-2] 2,0 ^2,1 „Entrez Gene: DRD5 dopamine receptor D5”.

[autogenerated1-3] Polymeropoulos MH, Xiao H, Merril CR (1991). „The human D₅ dopamine receptor (DRD5) maps on chromosome 4”. Genomics 11 (3): 777–778. DOI:10.1016/0888-7543(91)90091-R. PMID 1774076.

[pmid9588624-4] Sidhu A (1998). „Coupling of D₁ and D₅ dopamine receptors to multiple G proteins: Implications for understanding the diversity in receptor-G protein coupling”. Mol. Neurobiol. 16 (2): 125–134. DOI:10.1007/BF02740640. PMID 9588624.

[pmid16539400-5] 5,0 ^5,1 Mohr P, Decker M, Enzensperger C, Lehmann J (2006). „Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D₅-selective dopamine-receptor antagonist”. J. Med. Chem. 49 (6): 2110–2116. DOI:10.1021/jm051237e. PMID 16539400.

[pmid10659839-6] Liu, F; Wan Q, Pristupa Z B, Yu X M, Wang Y T, Niznik H B (January 2000). „Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors”. Nature (England) 403 (6767): 274–280. DOI:10.1038/35002014. ISSN 0028-0836. PMID 10659839.

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