Klatrin

Klatrin laki lanac
Klatrin laki lanac
Identifikatori
Simbol	Clathrin_lg_ch
Pfam	PF01086
InterPro	IPR000996
PROSITE	PDOC00196
Pfam
Dostupne proteinske strukture:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Klatrin, laki polipeptid (Lcb)
Klatrin, laki polipeptid (Lcb)
Identifikatori
Simbol	CLTB
Entrez	1212
HUGO	2091
OMIM	118970
RefSeq	NM_001834
UniProt	P09497
Ostali podaci
Lokus	Hromozom 4 q

Klatrin, laki polipeptid (Lca)
Klatrin, laki polipeptid (Lca)
Identifikatori
Simbol	CLTA
Entrez	1211
HUGO	2090
OMIM	118960
RefSeq	NM_007096
UniProt	P09496
Ostali podaci
Lokus	Hromozom 12 q23-q24

Klatrin, teški polipeptid (Hc)
Identifikatori
Simbol	CLTC
Alt. simboli	CLTCL2
Entrez	1213
HUGO	2092
OMIM	118955
RefSeq	NM_004859
UniProt	Q00610
Ostali podaci
Lokus	Hromozom 17 q11-qter

Klatrin, teškom polipeptidu sličan 1
Identifikatori
Simbol	CLTCL1
Alt. simboli	CLTCL
Entrez	8218
HUGO	2093
OMIM	601273
RefSeq	NM_001835
UniProt	P53675
Ostali podaci
Lokus	Hromozom 22 q11.2

Klatrinsko propelersko ponavljanje

terminalno domen klatrina u kompleksu sa tlpwdlwtt

Identifikatori

Simbol

Clathrin_propel

Pfam klan

Dostupne proteinske strukture:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Veza klatrinskog teškog lanca

Klatrinski terminalni domen u kompleksu sa tlpwdlwtt

Identifikatori

Simbol

Clathrin-link

Pfam klan

Dostupne proteinske strukture:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Klatrin je protein koji ima centralnu ulogu u formiranju vezikula. Barbara Pears je prva izolovala i imenovala klatrin 1975.^[1] On formira strukturu triskelionskog oblika koja se sastoji od tri klatrinska teška lanca i tri laka lanca. Kad se ove strukture slože nastaje polihedralna rešetka koja okružuje vezikulu. Pokrivajući proteini poput klatrina se koriste za formiranje malih vezikula kojima se molekuli mogu bezbedno trasportovati između ćelija. Endocitoza i egzocitoza vezikula omogućava ćelijama da razmenjuju nutrijente, da unose signalne receptore, da posreduju imunski respons nakon testiranja ekstracelularnog sveta, i uklanjaju ćelijski ostatke nakon zapaljenja tkiva. Povremeno ovaj mehanizam takođe služi kao način uklanjanja patogena ili toksina.

Reference

^ Pearse BM (1976). „Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles”. Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1255—9. PMC 430241 . PMID 1063406. doi:10.1073/pnas.73.4.1255.

Literatura

Wakeham DE, Chen CY, Greene B, Hwang PK, Brodsky FM (2003). „Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation”. The EMBO Journal. 22 (19): 4980—90. PMC 204494 . PMID 14517237. doi:10.1093/emboj/cdg511.
Ford MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, McMahon HT (2002). „Curvature of clathrin-coated pits driven by epsin”. Nature. 419 (6905): 361—6. PMID 12353027. doi:10.1038/nature01020.
Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T (2004). „Molecular model for a complete clathrin lattice from electron cryomicroscopy”. Nature. 432 (7017): 573—9. PMID 15502812. doi:10.1038/nature03079.
Mousavi SA, Malerød L, Berg T, Kjeken R (2004). „Clathrin-dependent endocytosis”. The Biochemical Journal. 377 (Pt 1): 1—16. PMC 1223844 . PMID 14505490. doi:10.1042/BJ20031000.
Smith CJ, Grigorieff N, Pearse BM (1998). „Clathrin coats at 21 A resolution: a cellular assembly designed to recycle multiple membrane receptors”. The EMBO Journal. 17 (17): 4943—53. PMC 1170823 . PMID 9724631. doi:10.1093/emboj/17.17.4943. (Model of Clathrin assembly)
Pérez-Gómez J, Moore I (2007). „Plant endocytosis: it is clathrin after all”. Current Biology : CB. 17 (6): R217—9. PMID 17371763. doi:10.1016/j.cub.2007.01.045. (Review on involvement of clathrin in plant endocytosis - proven recently)
Royle SJ, Bright NA, Lagnado L (2005). „Clathrin is required for the function of the mitotic spindle”. Nature. 434 (7037): 1152—7. PMID 15858577. doi:10.1038/nature03502.
Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM (2006). „Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly”. Traffic (Copenhagen, Denmark). 7 (12): 1688—700. PMID 17052248. doi:10.1111/j.1600-0854.2006.00499.x.
Edeling MA, Smith C, Owen D (2006). „Life of a clathrin coat: insights from clathrin and AP structures”. Nature Reviews Molecular Cell Biology. 7 (1): 32—44. PMID 16493411. doi:10.1038/nrm1786.

Vidi još

Spoljašnje veze

Eukaryotic Linear Motif resource motif class LIG_Clathr_ClatBox_1.html LIG_Clathr_ClatBox_1
Eukaryotic Linear Motif resource motif class LIG_Clathr_ClatBox_2.html LIG_Clathr_ClatBox_2
Struktura klatrina
Membranska sinamika

[pmid1063406-1] Pearse BM (1976). „Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles”. Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1255—9. PMC 430241 . PMID 1063406. doi:10.1073/pnas.73.4.1255.

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