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C-jun

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Oncogén JUN

Estructura tridimensional de la proteína c-Jun.
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Lista de códigos PDB
1A02 , 1FOS , 1JNM , 1JUN , 1S9K , 1T2K
Identificadores
Símbolos JUN (HGNC: 6204) AP1, c-Jun
Identificadores
externos
Locus Cr. 1 p32.1
Patrón de expresión de ARNm
ancho=250px
ancho=250px
ancho=250px
Más información
Ortólogos
Especies
Humano Ratón
Entrez
3725 16476
Ensembl
Véase HS Véase MM
UniProt
P05412 P05627
RefSeq
(ARNm)
NM_002228 NM_010591
RefSeq
(proteína) NCBI
NP_002219 NP_034721
Ubicación (UCSC)
Cr. 1:
59.25 – 59.25 Mb 		Cr. 4:
95.05 – 95.05 Mb
PubMed (Búsqueda)
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c-jun es el nombre de un gen que codifica la proteína c-Jun, la cual, tras combinarse con la proteína c-Fos, conforma el factor de transcripción AP-1. Inicialmente fue identificado como proteína p39 de unión a Fos y posteriormente fue redescubierta como el producto del gen c-jun. Su activación se produce por una doble fosforilación a través de la ruta JNK, pero también se ha descrito una función alternativa independiente de fosforilación. Se ha podido comprobar que el knockout de c-jun es letal. Sin embargo, animales transgénicos cuyo gen c-jun había sido mutado de modo que la proteína c-Jun no podía ser fosforilada (denominados c-JunAA), sí podían sobrevivir. La proteína c-Jun ha demostrado ser muy similar a una proteína del virus 17 de sarcoma aviar, la cual reconoce de un modo directo secuencias específicas del ADN para regular su expresión. El gen c-jun no posee intrones y se encuentra en una región cromosómica implicada en procesos de traslocaciones y deleciones en diversas patologías humanas.[1]​

Interacciones

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La proteína c-Jun ha demostrado ser capaz de interaccionar con:

Referencias

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  1. ↑ «Entrez Gene: JUN jun oncogene». 
  2. ↑ Pessah, M; Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier J M, Atfi A (mayo. de 2001). «c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (11): 6198-203. ISSN 0027-8424. PMID 11371641. doi:10.1073/pnas.101579798. 
  3. ↑ Verger, A; Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M (mayo. de 2001). «Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation». J. Biol. Chem. (United States) 276 (20): 17181-9. ISSN 0021-9258. PMID 11278640. doi:10.1074/jbc.M010208200. 
  4. ↑ Nishitani, J; Nishinaka T, Cheng C H, Rong W, Yokoyama K K, Chiu R (Feb. de 1999). «Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site». J. Biol. Chem. (UNITED STATES) 274 (9): 5454-61. ISSN 0021-9258. PMID 10026157. 
  5. ↑ Sano, Y; Tokitou F; Dai P; Maekawa T; Yamamoto T; Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098-105. ISSN 0021-9258. PMID 9786917. 
  6. ↑ Newell, C L; Deisseroth A B, Lopez-Berestein G (Jul. de 1994). «Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene». J. Leukoc. Biol. (UNITED STATES) 56 (1): 27-35. ISSN 0741-5400. PMID 8027667. 
  7. ↑ Kara, C J; Liou H C, Ivashkiv L B, Glimcher L H (Apr. de 1990). «A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain». Mol. Cell. Biol. (UNITED STATES) 10 (4): 1347-57. ISSN 0270-7306. PMID 2320002. 
  8. ↑ a b Hai, T; Curran T (mayo. de 1991). «Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 88 (9): 3720-4. ISSN 0027-8424. PMID 1827203. 
  9. ↑ Zhong, Hongjun; Zhu Jianhua, Zhang Hao, Ding Lihua, Sun Yan, Huang Cuifen, Ye Qinong (Dec. de 2004). «COBRA1 inhibits AP-1 transcriptional activity in transfected cells». Biochem. Biophys. Res. Commun. (United States) 325 (2): 568-73. ISSN 0006-291X. PMID 15530430. doi:10.1016/j.bbrc.2004.10.079. 
  10. ↑ Hu, Yan-Fen; Li Rong (Jun. de 2002). «JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction». Genes Dev. (United States) 16 (12): 1509-17. ISSN 0890-9369. PMID 12080089. doi:10.1101/gad.995502. 
  11. ↑ Ito, T; Yamauchi M; Nishina M; Yamamichi N; Mizutani T; Ui M; Murakami M; Iba H (Jan. de 2001). «Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers». J. Biol. Chem. (United States) 276 (4): 2852-7. ISSN 0021-9258. PMID 11053448. doi:10.1074/jbc.M009633200. 
  12. ↑ a b Pognonec, P; Boulukos K E, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (mayo. de 1997). «Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity». Oncogene (ENGLAND) 14 (17): 2091-8. ISSN 0950-9232. PMID 9160889. doi:10.1038/sj.onc.1201046. 
  13. ↑ Glover, J N; Harrison S C (Jan. de 1995). «Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA». Nature (ENGLAND) 373 (6511): 257-61. ISSN 0028-0836. PMID 7816143. doi:10.1038/373257a0. 
  14. ↑ a b Yang, X; Chen Y; Gabuzda D (Sep. de 1999). «ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB». J. Biol. Chem. (UNITED STATES) 274 (39): 27981-8. ISSN 0021-9258. PMID 10488148. 
  15. ↑ Nomura, N; Zu Y L, Maekawa T, Tabata S, Akiyama T, Ishii S (Feb. de 1993). «Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1». J. Biol. Chem. (UNITED STATES) 268 (6): 4259-66. ISSN 0021-9258. PMID 8440710. 
  16. ↑ Finkel, T; Duc J, Fearon E R, Dang C V, Tomaselli G F (Jan. de 1993). «Detection and modulation in vivo of helix-loop-helix protein-protein interactions». J. Biol. Chem. (UNITED STATES) 268 (1): 5-8. ISSN 0021-9258. PMID 8380166. 
  17. ↑ a b c Venugopal, R; Jaiswal A K (Dec. de 1998). «Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes». Oncogene (ENGLAND) 17 (24): 3145-56. ISSN 0950-9232. PMID 9872330. doi:10.1038/sj.onc.1202237. 
  18. ↑ Westermarck, Jukka; Weiss Carsten, Saffrich Rainer, Kast Jürgen, Musti Anna-Maria, Wessely Matthias, Ansorge Wilhelm, Séraphin Bertrand, Wilm Matthias, Valdez Benigno C, Bohmann Dirk (Feb. de 2002). «The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription». EMBO J. (England) 21 (3): 451-60. ISSN 0261-4189. PMID 11823437. 
  19. ↑ a b Franklin, C C; McCulloch A V, Kraft A S (Feb. de 1995). «In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB». Biochem. J. (ENGLAND). 305 ( Pt 3): 967-74. ISSN 0264-6021. PMID 7848298. 
  20. ↑ Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. de 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23): 6277-88. ISSN 0261-4189. PMID 14633987. doi:10.1093/emboj/cdg605. 
  21. ↑ Nishitoh, H; Saitoh M; Mochida Y; Takeda K; Nakano H; Rothe M; Miyazono K; Ichijo H (Sep. de 1998). «ASK1 is essential for JNK/SAPK activation by TRAF2». Mol. Cell (UNITED STATES) 2 (3): 389-95. ISSN 1097-2765. PMID 9774977. 
  22. ↑ Dérijard, B; Hibi M, Wu I H, Barrett T, Su B, Deng T, Karin M, Davis R J (Mar. de 1994). «JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain». Cell (UNITED STATES) 76 (6): 1025-37. ISSN 0092-8674. PMID 8137421. 
  23. ↑ Yazgan, Oya; Pfarr Curt M (Aug. de 2002). «Regulation of two JunD isoforms by Jun N-terminal kinases». J. Biol. Chem. (United States) 277 (33): 29710-8. ISSN 0021-9258. PMID 12052834. doi:10.1074/jbc.M204552200. 
  24. ↑ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. de 2001). «Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death». J. Biol. Chem. (United States) 276 (39): 36530-4. ISSN 0021-9258. PMID 11479302. doi:10.1074/jbc.M104837200. 
  25. ↑ Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (Apr. de 1996). «Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation». J. Biol. Chem. (UNITED STATES) 271 (15): 8971-6. ISSN 0021-9258. PMID 8621542. 
  26. ↑ Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. de 1995). «Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction». J. Cell. Sci. (ENGLAND). 108 ( Pt 11): 3599-609. ISSN 0021-9533. PMID 8586671. 
  27. ↑ Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (Jul. de 1997). «Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337-42. ISSN 0027-8424. PMID 9207092. 
  28. ↑ Lee, S K; Kim J H, Lee Y C, Cheong J, Lee J W (Apr. de 2000). «Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor». J. Biol. Chem. (UNITED STATES) 275 (17): 12470-4. ISSN 0021-9258. PMID 10777532. 
  29. ↑ Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. de 2004). «Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase». Science (United States) 303 (5662): 1371-4. PMID 14739464. doi:10.1126/science.1093549. 
  30. ↑ Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (mayo. de 2003). «Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity». J. Biol. Chem. (United States) 278 (22): 19682-90. ISSN 0021-9258. PMID 12615916. doi:10.1074/jbc.M212681200. 
  31. ↑ Wulf, G M; Ryo A, Wulf G G, Lee S W, Niu T, Petkova V, Lu K P (Jul. de 2001). «Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1». EMBO J. (England) 20 (13): 3459-72. ISSN 0261-4189. PMID 11432833. doi:10.1093/emboj/20.13.3459. 
  32. ↑ Zhang, Y; Feng X H, Derynck R (Aug. de 1998). «Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription». Nature (ENGLAND) 394 (6696): 909-13. ISSN 0028-0836. PMID 9732876. doi:10.1038/29814. 
  33. ↑ Verrecchia, F; Pessah M; Atfi A; Mauviel A (Sep. de 2000). «Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation». J. Biol. Chem. (UNITED STATES) 275 (39): 30226-31. ISSN 0021-9258. PMID 10903323. doi:10.1074/jbc.M005310200. 
  34. ↑ Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. de 1999). «Smads bind directly to the Jun family of AP-1 transcription factors». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844-9. ISSN 0027-8424. PMID 10220381. 
  35. ↑ Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul. de 2002). «Novel transcription coactivator complex containing activating signal cointegrator 1». Mol. Cell. Biol. (United States) 22 (14): 5203-11. ISSN 0270-7306. PMID 12077347. 
  36. ↑ a b Yamaguchi, Y; Wada T; Suzuki F; Takagi T; Hasegawa J; Handa H (Aug. de 1998). «Casein kinase II interacts with the bZIP domains of several transcription factors». Nucleic Acids Res. (ENGLAND) 26 (16): 3854-61. ISSN 0305-1048. PMID 9685505. 
  37. ↑ a b Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E (Oct. de 1999). «Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation». Mol. Cell. Biol. (UNITED STATES) 19 (10): 7138-46. ISSN 0270-7306. PMID 10490649. 
  38. ↑ Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. de 2002). «Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene». J. Immunol. (United States) 169 (4): 1922-9. ISSN 0022-1767. PMID 12165517. 
  39. ↑ Na, S Y; Choi J E, Kim H J, Jhun B H, Lee Y C, Lee J W (Oct. de 1999). «Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation». J. Biol. Chem. (UNITED STATES) 274 (40): 28491-6. ISSN 0021-9258. PMID 10497212. 
  40. ↑ Sato, N; Sadar M D, Bruchovsky N, Saatcioglu F, Rennie P S, Sato S, Lange P H, Gleave M E (Jul. de 1997). «Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP». J. Biol. Chem. (UNITED STATES) 272 (28): 17485-94. ISSN 0021-9258. PMID 9211894. 
  41. ↑ Basuyaux, J P; Ferreira E, Stéhelin D, Butticè G (Oct. de 1997). «The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner». J. Biol. Chem. (UNITED STATES) 272 (42): 26188-95. ISSN 0021-9258. PMID 9334186. 
  42. ↑ Pearson, Andree G; Gray Carol W, Pearson John F, Greenwood Jeffrey M, During Matthew J, Dragunow Michael (Dec. de 2003). «ATF3 enhances c-Jun-mediated neurite sprouting». Brain Res. Mol. Brain Res. (Netherlands) 120 (1): 38-45. ISSN 0169-328X. PMID 14667575. 
  43. ↑ Chen, B P; Wolfgang C D, Hai T (Mar. de 1996). «Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10». Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157-68. ISSN 0270-7306. PMID 8622660. 
  44. ↑ Moreau, A; Yotov W V, Glorieux F H, St-Arnaud R (Mar. de 1998). «Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1312-21. ISSN 0270-7306. PMID 9488446. 
  45. ↑ Claret, F X; Hibi M; Dhut S; Toda T; Karin M (Oct. de 1996). «A new group of conserved coactivators that increase the specificity of AP-1 transcription factors». Nature (ENGLAND) 383 (6599): 453-7. ISSN 0028-0836. PMID 8837781. doi:10.1038/383453a0. 
  46. ↑ Ubeda, M; Vallejo M, Habener J F (Nov. de 1999). «CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589-99. ISSN 0270-7306. PMID 10523647. 
  47. ↑ Jung, Dong-Ju; Na Soon-Young, Na Doe Sun, Lee Jae Woon (Jan. de 2002). «Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors». J. Biol. Chem. (United States) 277 (2): 1229-34. ISSN 0021-9258. PMID 11704680. doi:10.1074/jbc.M110417200. 
  48. ↑ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283-93. ISSN 0021-9258. PMID 10567404. 
  49. ↑ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. de 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6): 915-25. ISSN 0888-8809. PMID 10847592. 
  50. ↑ Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. de 1998). «Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits». J. Biol. Chem. (UNITED STATES) 273 (27): 16651-4. ISSN 0021-9258. PMID 9642216. 
  51. ↑ Bengal, E; Ransone L, Scharfmann R, Dwarki V J, Tapscott S J, Weintraub H, Verma I M (Feb. de 1992). «Functional antagonism between c-Jun and MyoD proteins: a direct physical association». Cell (UNITED STATES) 68 (3): 507-19. ISSN 0092-8674. PMID 1310896. 
  52. ↑ a b Hess, J; Porte D; Munz C; Angel P (Jun. de 2001). «AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element». J. Biol. Chem. (United States) 276 (23): 20029-38. ISSN 0021-9258. PMID 11274169. doi:10.1074/jbc.M010601200. 
  53. ↑ a b D'Alonzo, Richard C; Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C (Jan. de 2002). «Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation». J. Biol. Chem. (United States) 277 (1): 816-22. ISSN 0021-9258. PMID 11641401. doi:10.1074/jbc.M107082200. 

Véase también

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Enlaces externos

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